Infection homeostasis: implications for therapeutic and immune programming of metabolism in controlling infection

Konstantinos Kotzamanis, Ana Angulo, Peter Ghazal

Research output: Contribution to journalArticlepeer-review

Abstract

Homeostasis underpins at a systems level the regulatory control of immunity and metabolism. While physiologically these systems are often viewed as independent, there is increasing evidence showing a tight coupling between immune and metabolic functions. Critically upon infection, the homeostatic regulation for both immune and metabolic pathways is altered yet these changes are often investigated in isolation. Here, we summarise our current understanding of these processes in the context of a clinically relevant pathogen, cytomegalovirus. We synthesise from the literature an integrative view of a coupled immune–metabolic infection process, centred on sugar and lipid metabolism. We put forward the notion that understanding immune control of key metabolic enzymatic steps in infection will promote the future development of novel therapeutic modalities based on metabolic modifiers that either enhance protection or inhibit infection.

Original languageEnglish
Pages (from-to)395-407
Number of pages13
JournalMedical Microbiology and Immunology
Volume204
Issue number3
Early online date24 Mar 2015
DOIs
Publication statusPublished - Jun 2015

Keywords

  • CMV
  • Fatty acid synthesis
  • Glycolysis
  • Infection
  • Inflammation
  • Metabolism

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