Projects per year
Homeostasis underpins at a systems level the regulatory control of immunity and metabolism. While physiologically these systems are often viewed as independent, there is increasing evidence showing a tight coupling between immune and metabolic functions. Critically upon infection, the homeostatic regulation for both immune and metabolic pathways is altered yet these changes are often investigated in isolation. Here, we summarise our current understanding of these processes in the context of a clinically relevant pathogen, cytomegalovirus. We synthesise from the literature an integrative view of a coupled immune–metabolic infection process, centred on sugar and lipid metabolism. We put forward the notion that understanding immune control of key metabolic enzymatic steps in infection will promote the future development of novel therapeutic modalities based on metabolic modifiers that either enhance protection or inhibit infection.
|Number of pages||13|
|Journal||Medical Microbiology and Immunology|
|Early online date||24 Mar 2015|
|Publication status||Published - Jun 2015|
- Fatty acid synthesis
FingerprintDive into the research topics of 'Infection homeostasis: implications for therapeutic and immune programming of metabolism in controlling infection'. Together they form a unique fingerprint.
- 2 Finished
MicroRNA coupling of the sterol metabolic network to the antiviral immune response
1/07/13 → 31/08/16
SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh
Millar, A., Beggs, J., Ghazal, P., Goryanin, I., Hillston, J., Plotkin, G., Tollervey, D., Walton, A. & Robertson, K.
8/01/07 → 31/12/12