Infection with the EU genotype of PRRSV as cause of central-nervous disorders in suckling pigs. A case report

E. Grosse Beilage, B. Brakmann, H. Nathues, T. Opriessnig, K. Fiebig, I. Greiser-Wilke, W. Baumgärtner

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Objective: A herd comprising 380 sows showed high rates of late abortions and litters with dead and weak born piglets. Beside these signs, which are typical for PRRS the newborn piglets showed distinct central nervous disorders. Material and methods: Special diagnostic tests (PCR, histopathology, immunohistochemistry) were performed to establish a diagnosis for the symptoms in the sow herd and to find out the cause of the central nervous disorders in the suckling pigs. Results: The EU genotype of PRRSV could be detected by PCR in tissues from two of two fetuses and in sera or lung tissue from 21 of 24 piglets. In the cerebrum from one of six piglets with central nervous symptoms PRRSV could be demonstrated by immunohistochemistry. Classical swine fever, Aujeszky's disease and infections with porcine enterovirus or porcine circovirus 2 were excluded. Conclusion and clinical relevance: The tentative clinical diagnosis could be confirmed by the detection of the EU genotype of PRRSV in several samples. Up to date, central nervous signs in piglets caused by PRRSV were only known for infections with the US genotype. That the EU genotype can also induce central nervous symptoms was demonstrated by the detection of PRRSV in macrophages in the cerebrum by immunohistochemistry.
Original languageEnglish
Pages (from-to)294-298
Number of pages5
JournalTierärztliche Praxis Großtiere
Issue number4
Publication statusPublished - 1 Jan 2007


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