Projects per year
Abstract
Objective
We investigated clinical features, microbiology, and outcomes of incident infective endocarditis (IE) hospitalizations in patients with end-stage kidney disease (ESKD) requiring dialysis or kidney transplantation over 25 years.
Methods
We conducted a retrospective, population-based cohort study linking national datasets in Scotland. Between 01/01/1990 and 12/31/2014, patients hospitalized with IE and with a history of ESKD were identified from national inpatient records and linked to national hospitalization and mortality data. From 01/01/2008, individual IE hospitalizations were additionally linked to national microbiology data. Multivariable logistic regression, adjusting for patient demographics and comorbidities, evaluated the association between ESKD and all-cause death at one and three years.
Results
Of 7,638 incident IE hospitalizations between 1990 and 2014, 2.8% (216/7,638) occurred in 210 patients with ESKD and 97.2% (7,422/7,638) occurred in 7,303 patients without ESKD. Positive blood cultures were identified in 42% (950/2,267) of incident IE hospitalizations from 2008. Staphylococcus aureus was isolated in 25.9% (21/81) and 12.8% (280/2,186) of patients with and without ESKD, respectively (p=0.002). ESKD was associated with an increased odds of death at one (44.9% versus 31.4%; adjusted odds ratio [aOR] 2.47, 95% confidence interval [CI] 1.85 to 3.30, p<0.001) and three years (63.9% versus 42.8%; aOR 3.77, 95% CI 2.79 to 5.12, p<0.001).
Conclusions
IE is associated with a poor prognosis in patients with ESKD, especially in the long-term. Compared to patients without ESKD, patients with ESKD were twice as likely to die within one year, and three times as likely to die within three years of IE hospitalization.
Original language | English |
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Journal | Journal of the American Heart Association |
DOIs | |
Publication status | Published - 28 Sept 2021 |
Fingerprint
Dive into the research topics of 'Infective endocarditis hospitalizations & outcomes in patients with end-stage kidney disease: a nationwide data-linkage study'. Together they form a unique fingerprint.Projects
- 4 Finished
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The burden of cardiovascular disease in patients with kidney disease: temporal trends and treatment gaps
1/02/21 → 31/01/23
Project: Research
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High-sensitivity Cardiac Troponin In The Prevention Of Cardiovascular Disease
Shah, A., Mills, N. & Newby, D.
1/08/19 → 31/07/20
Project: Research
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