Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling

Colin Farquharson*, S. Faisal Ahmed

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Linear bone growth is widely recognized to be adversely affected in children with chronic kidney disease (CKD) and other chronic inflammatory disorders. The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) pathway is anabolic to the skeleton and inflammatory cytokines compromise bone growth through a number of different mechanisms, which include interference with the systemic as well as the tissue-level GH/IGF-1 axis. Despite attempts to promote growth and control disease, there are an increasing number of reports of the persistence of poor growth in a substantial proportion of patients receiving rhGH and/or drugs that block cytokine action. Thus, there is an urgent need to consider better and alternative forms of therapy that are directed specifically at the mechanism of the insult which leads to abnormal bone health. Suppressor of cytokine signaling 2 (SOCS2) expression is increased in inflammatory conditions including CKD, and is a recognized inhibitor of GH signaling. Therefore, in this review, we will focus on the premise that SOCS2 signaling represents a critical pathway in growth plate chondrocytes through which pro-inflammatory cytokines alter both GH/IGF-1 signaling and cellular function.

Original languageEnglish
Pages (from-to)547-556
Number of pages10
JournalPediatric Nephrology
Volume28
Issue number4
Early online date14 Aug 2012
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Chronic kidney disease
  • Inflammatory cytokines
  • MICE LACKING SUPPRESSOR
  • SOCS2
  • IGF-I
  • Bone growth
  • CYTOKINE SIGNALING-2
  • TARGETED DISRUPTION
  • EMBRYONIC LETHALITY
  • CHRONIC-RENAL-FAILURE
  • HORMONE RESISTANCE
  • FACTOR-I
  • GH/IGF-1 axis
  • CHRONIC KIDNEY-DISEASE
  • PLATE CHONDROGENESIS

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