Inflammation and performance status: the cornerstones of prognosis in advanced cancer

Bruna Rocha, Ross Dolan, Carlos Paiva, Josh McGovern, Bianca Paiva, Daniel Preto, Donald C McMillan, Yara Maia, Barry J A Laird

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Abstract
Background
In advanced cancer, although performance status (PS), systemic inflammatory response and nutritional status are known to have prognostic value, geographical variations and sociodemographic indexes may also impact survival. This study compares validated prognostic factors in two international cohorts and establishes a prognostic framework for treatment.
Methods
Two international biobanks of patients (n=1.518) with advanced cancer were analyzed. Prognostic factors (Eastern Cooperative Oncology Group Performance Status [ECOG-PS], body mass index [BMI] and modified Glasgow Prognostic Score [mGPS]) were assessed. The relationship between these and survival was examined using Kaplan–Meier and Cox regression methods.
Results
According to multivariate analysis, in the European cohort the most highly predictive factors were BMI 28 kg/m2) to 44% (mGPS 2, BMI Conclusion
The established prognostic factors that were compared had similar prognostic capacity in both cohorts. A high ECOG-PS and a high mGPS as outlined in the ECOG-PS/mGPS framework were consistently associated with poorer survival of patients with advanced cancer in the prospective European and Brazilian cohorts.
Original languageEnglish
JournalJournal of Pain and Symptom Management
Early online date6 Dec 2022
DOIs
Publication statusE-pub ahead of print - 6 Dec 2022

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