Projects per year
Abstract
Foxp3(+) regulatory T (Treg) cells prevent the development of autoimmunity and immunopathology, as well as maintaining homeostasis and tolerance to commensal microorganisms. The suppressive activity of Treg cells is their defining characteristic, generating great interest in their therapeutic potential. However, suppressive and effector functions are not entirely exclusive. Considerable evidence points to the ability of supposedly anti-inflammatory Foxp3-expressing Treg cells to also express transcription factors that have been characterized as cardinal drivers of T effector cell function. We will consider the mounting evidence that Treg cells can function in non-suppressive capacities and review the impetus for this functional change, its relevance to developing immune and autoimmune responses and its significance to the development of Treg-based therapies.
Original language | English |
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Pages (from-to) | 194-205 |
Number of pages | 12 |
Journal | Immunology |
Volume | 146 |
Issue number | 2 |
DOIs | |
Publication status | Published - Oct 2015 |
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Dive into the research topics of 'Inflammation-associated genes: risks and benefits to Foxp3(+) regulatory T-cell function'. Together they form a unique fingerprint.Projects
- 2 Finished
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The role of T-bet in Foxp3+ regulatory cell-mediated protection from autoimmune inflammation
Anderton, S. (Principal Investigator) & O'Connor, R. (Co-investigator)
1/04/12 → 31/03/15
Project: Research
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Immune cell interactions in the inflammed CNS
Anderton, S. (Principal Investigator) & O'Connor, R. (Co-investigator)
1/04/09 → 30/09/14
Project: Research