Inflammation fires up cancer metastasis

Research output: Contribution to journalReview articlepeer-review

Abstract

Metastatic disease is the major challenge of cancer that accounts for over 90% of total cancer lethality. Mounting clinical and preclinical data now indicate that inflammation, a potent immune and repair response, is indispensable for metastasis. In this review we describe our current understanding of how major inflammatory cells contribute to metastatic cascade with a focus on the primary tumour. We also discuss exciting new directions for future research and novel therapeutic approaches to tackle metastatic disease through targeting inflammation.
Original languageEnglish
Journalseminars in cancer biology
Early online date31 Aug 2017
DOIs
Publication statusE-pub ahead of print - 31 Aug 2017

Keywords

  • metastasis
  • Inflamation
  • cancer
  • immunology

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