Inflammatory activity in Crohn's disease: CE-US

Vincenzo Migaleddu, Emilio Quaia, Domenico Scanu, Serra Carla, Michele Bertolotto, Girolamo Campisi, Danilo Sirigu, Giuseppe Virgilio

Research output: Contribution to journalArticlepeer-review


The evaluation of inflammatory activity in Crohn's disease (CD), a crucial aspect of treatment planning and monitoring, is currently based on a sum of clinical data and imaging findings. Among the contrast enhanced cross-sectional imaging techniques (CE-US, CE-CT, CE-MR), CE-US is less invasive, more comfortable for the patient, and has significant diagnostic accuracy. In addition, it is a portable, easily repeatable, well tolerated, and ionizing radiation-free imaging modality. CE-US has been introduced as effective method in the quantitative and qualitative evaluation of CD inflammatory activity. CE-US might help in characterizing bowel-wall thickening by differentiating inflammatory neovascularisation, edema, and fibrosis. The recent chance to evaluate the bowel-wall stiffness by US elastography imaging could allow further assessment of fibrosis that characterizes the evolution of the inflammatory activity.

Original languageEnglish
Pages (from-to)142-8
Number of pages7
JournalAbdominal Imaging
Issue number2
Publication statusPublished - Apr 2011


  • Contrast Media
  • Crohn Disease
  • Humans
  • Inflammation
  • Microbubbles
  • Ultrasonography


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