Inflammatory cytokines in juvenile idiopathic arthritis: effects on physical growth and the insulin-like-growth factor axis

S. C. Wong; Vicky MacRae; J. A. Gracie; I. B. McInnes; P. Galea; J. Gardner-Medwin; S. F. Ahmed

doi:10.1016/j.ghir.2008.01.006

Inflammatory cytokines in juvenile idiopathic arthritis: effects on physical growth and the insulin-like-growth factor axis

S. C. Wong, Vicky MacRae, J. A. Gracie, I. B. McInnes, P. Galea, J. Gardner-Medwin, S. F. Ahmed

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Objective

To investigate the relationship between markers of inflammation with physical growth and systemic markers of GH secretion in JIA.

Design

This is a cross sectional prospective study of patients with JIA recruited during therapeutic arthrocentesis of 17 children with JIA (F, 10): 8 oligoarticular (OJIA) and 9 polyarticular (PJIA).

Results

Median adjusted height (AHt) SDS was −0.3 (−2.2 to 1.6). Serum ALS SDS (median −1.3, range −2.7 to −0.6) was reduced compared with serum IGFBP-3 SDS (median −0.5, range −7.7 to 2.3) and IGF-1 SDS (median −0.2, range −0.5 to 0.5). Log serum IL5 (95% CI −3.25, −0.81) and log serum IL15 (95% CI −9.58, −4.10) were independent factors associated with AHt SDS. Inflammatory cytokines individually showed no association with IGF-1, IGFBP-1, -2, -3 and ALS.

Conclusion

Children with JIA and mild degree of growth retardation show decreased ALS and IGFBP-3. Cytokines did not show an association to systemic markers of GH secretion. However, this study reports the novel, preliminary association between serum levels of IL5 and IL15 and the extent of short stature.

Original language	English
Pages (from-to)	369-378
Number of pages	10
Journal	Growth Hormone and IGF Research
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/j.ghir.2008.01.006
Publication status	Published - Oct 2008

Keywords / Materials (for Non-textual outputs)

Inflammation
Cytokines
Growth
Insulin-like growth factor 1
Juvenile idiopathic arthritis

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10.1016/j.ghir.2008.01.006

http://www.sciencedirect.com/science/article/pii/S1096637408000075

Cite this

@article{3bd3403eca424eef9a551abc223b30a2,

title = "Inflammatory cytokines in juvenile idiopathic arthritis: effects on physical growth and the insulin-like-growth factor axis",

abstract = "ObjectiveTo investigate the relationship between markers of inflammation with physical growth and systemic markers of GH secretion in JIA. DesignThis is a cross sectional prospective study of patients with JIA recruited during therapeutic arthrocentesis of 17 children with JIA (F, 10): 8 oligoarticular (OJIA) and 9 polyarticular (PJIA). ResultsMedian adjusted height (AHt) SDS was −0.3 (−2.2 to 1.6). Serum ALS SDS (median −1.3, range −2.7 to −0.6) was reduced compared with serum IGFBP-3 SDS (median −0.5, range −7.7 to 2.3) and IGF-1 SDS (median −0.2, range −0.5 to 0.5). Log serum IL5 (95% CI −3.25, −0.81) and log serum IL15 (95% CI −9.58, −4.10) were independent factors associated with AHt SDS. Inflammatory cytokines individually showed no association with IGF-1, IGFBP-1, -2, -3 and ALS. ConclusionChildren with JIA and mild degree of growth retardation show decreased ALS and IGFBP-3. Cytokines did not show an association to systemic markers of GH secretion. However, this study reports the novel, preliminary association between serum levels of IL5 and IL15 and the extent of short stature.",

keywords = "Inflammation, Cytokines, Growth, Insulin-like growth factor 1, Juvenile idiopathic arthritis",

author = "Wong, {S. C.} and Vicky MacRae and Gracie, {J. A.} and McInnes, {I. B.} and P. Galea and J. Gardner-Medwin and Ahmed, {S. F.}",

year = "2008",

month = oct,

doi = "10.1016/j.ghir.2008.01.006",

language = "English",

volume = "18",

pages = "369--378",

journal = "Growth Hormone and IGF Research",

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T1 - Inflammatory cytokines in juvenile idiopathic arthritis: effects on physical growth and the insulin-like-growth factor axis

AU - Wong, S. C.

AU - MacRae, Vicky

AU - Gracie, J. A.

AU - McInnes, I. B.

AU - Galea, P.

AU - Gardner-Medwin, J.

AU - Ahmed, S. F.

PY - 2008/10

Y1 - 2008/10

N2 - ObjectiveTo investigate the relationship between markers of inflammation with physical growth and systemic markers of GH secretion in JIA. DesignThis is a cross sectional prospective study of patients with JIA recruited during therapeutic arthrocentesis of 17 children with JIA (F, 10): 8 oligoarticular (OJIA) and 9 polyarticular (PJIA). ResultsMedian adjusted height (AHt) SDS was −0.3 (−2.2 to 1.6). Serum ALS SDS (median −1.3, range −2.7 to −0.6) was reduced compared with serum IGFBP-3 SDS (median −0.5, range −7.7 to 2.3) and IGF-1 SDS (median −0.2, range −0.5 to 0.5). Log serum IL5 (95% CI −3.25, −0.81) and log serum IL15 (95% CI −9.58, −4.10) were independent factors associated with AHt SDS. Inflammatory cytokines individually showed no association with IGF-1, IGFBP-1, -2, -3 and ALS. ConclusionChildren with JIA and mild degree of growth retardation show decreased ALS and IGFBP-3. Cytokines did not show an association to systemic markers of GH secretion. However, this study reports the novel, preliminary association between serum levels of IL5 and IL15 and the extent of short stature.

AB - ObjectiveTo investigate the relationship between markers of inflammation with physical growth and systemic markers of GH secretion in JIA. DesignThis is a cross sectional prospective study of patients with JIA recruited during therapeutic arthrocentesis of 17 children with JIA (F, 10): 8 oligoarticular (OJIA) and 9 polyarticular (PJIA). ResultsMedian adjusted height (AHt) SDS was −0.3 (−2.2 to 1.6). Serum ALS SDS (median −1.3, range −2.7 to −0.6) was reduced compared with serum IGFBP-3 SDS (median −0.5, range −7.7 to 2.3) and IGF-1 SDS (median −0.2, range −0.5 to 0.5). Log serum IL5 (95% CI −3.25, −0.81) and log serum IL15 (95% CI −9.58, −4.10) were independent factors associated with AHt SDS. Inflammatory cytokines individually showed no association with IGF-1, IGFBP-1, -2, -3 and ALS. ConclusionChildren with JIA and mild degree of growth retardation show decreased ALS and IGFBP-3. Cytokines did not show an association to systemic markers of GH secretion. However, this study reports the novel, preliminary association between serum levels of IL5 and IL15 and the extent of short stature.

KW - Inflammation

KW - Cytokines

KW - Growth

KW - Insulin-like growth factor 1

KW - Juvenile idiopathic arthritis

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U2 - 10.1016/j.ghir.2008.01.006

DO - 10.1016/j.ghir.2008.01.006

M3 - Article

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EP - 378

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

IS - 5

ER -

Inflammatory cytokines in juvenile idiopathic arthritis: effects on physical growth and the insulin-like-growth factor axis

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