Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase

Ali Roghanian; Ellen M Drost; William MacNee; Sarah E M Howie; Jean-Michel Sallenave

doi:10.1164/rccm.200605-632OC

Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase

Ali Roghanian, Ellen M Drost, William MacNee, Sarah E M Howie, Jean-Michel Sallenave

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Continuous episodes of infection are a feature of lung diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Lung antigen-presenting dendritic cells (DCs) sample inhaled antigen to initiate immune responses. Therefore, we hypothesized that inflammatory mediators, such as neutrophil elastase (NE) released into the lung, may be able to modulate their activity.

Original language	English
Pages (from-to)	1189-98
Number of pages	10
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	174
Issue number	11
DOIs	https://doi.org/10.1164/rccm.200605-632OC
Publication status	Published - 1 Dec 2006

Keywords / Materials (for Non-textual outputs)

Adult
Aged
Animals
Antigen Presentation
Antigens, CD40
Antigens, CD80
Antigens, CD86
Blotting, Western
Cystic Fibrosis
Cytokines
Dendritic Cells
Female
Humans
Immunohistochemistry
Leukocyte Elastase
Male
Mice
Mice, Inbred BALB C
Middle Aged
Phenotype
Pulmonary Disease, Chronic Obstructive
Sputum

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10.1164/rccm.200605-632OC

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title = "Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase",

abstract = "Continuous episodes of infection are a feature of lung diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Lung antigen-presenting dendritic cells (DCs) sample inhaled antigen to initiate immune responses. Therefore, we hypothesized that inflammatory mediators, such as neutrophil elastase (NE) released into the lung, may be able to modulate their activity.",

keywords = "Adult, Aged, Animals, Antigen Presentation, Antigens, CD40, Antigens, CD80, Antigens, CD86, Blotting, Western, Cystic Fibrosis, Cytokines, Dendritic Cells, Female, Humans, Immunohistochemistry, Leukocyte Elastase, Male, Mice, Mice, Inbred BALB C, Middle Aged, Phenotype, Pulmonary Disease, Chronic Obstructive, Sputum",

author = "Ali Roghanian and Drost, {Ellen M} and William MacNee and Howie, {Sarah E M} and Jean-Michel Sallenave",

year = "2006",

month = dec,

day = "1",

doi = "10.1164/rccm.200605-632OC",

language = "English",

volume = "174",

pages = "1189--98",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1073-449X",

publisher = "American Thoracic Society",

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T1 - Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase

AU - Roghanian, Ali

AU - Drost, Ellen M

AU - MacNee, William

AU - Howie, Sarah E M

AU - Sallenave, Jean-Michel

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Continuous episodes of infection are a feature of lung diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Lung antigen-presenting dendritic cells (DCs) sample inhaled antigen to initiate immune responses. Therefore, we hypothesized that inflammatory mediators, such as neutrophil elastase (NE) released into the lung, may be able to modulate their activity.

AB - Continuous episodes of infection are a feature of lung diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Lung antigen-presenting dendritic cells (DCs) sample inhaled antigen to initiate immune responses. Therefore, we hypothesized that inflammatory mediators, such as neutrophil elastase (NE) released into the lung, may be able to modulate their activity.

KW - Adult

KW - Aged

KW - Animals

KW - Antigen Presentation

KW - Antigens, CD40

KW - Antigens, CD80

KW - Antigens, CD86

KW - Blotting, Western

KW - Cystic Fibrosis

KW - Cytokines

KW - Dendritic Cells

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Leukocyte Elastase

KW - Male

KW - Mice

KW - Mice, Inbred BALB C

KW - Middle Aged

KW - Phenotype

KW - Pulmonary Disease, Chronic Obstructive

KW - Sputum

U2 - 10.1164/rccm.200605-632OC

DO - 10.1164/rccm.200605-632OC

M3 - Article

C2 - 16959917

SN - 1073-449X

VL - 174

SP - 1189

EP - 1198

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 11

ER -

Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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