Inflammatory pathways in endometrial disorders

Research output: Contribution to journalArticlepeer-review

Abstract

Complex interactions between the endocrine and immune systems govern the key endometrial events of implantation and menstruation. In contrast to other tissue sites, cyclical endometrial inflammation is physiological. However, dysregulation of this inflammatory response can lead to endometrial disorders. This review examines the inflammatory processes occurring in the normal endometrium during menstruation and implantation, highlighting recent advances in our understanding and gaps in current knowledge. Subsequently, the role of inflammatory pathways in the pathology of various common endometrial conditions is discussed, including heavy menstrual bleeding, dysmenorrhoea (painful periods), uterine fibroids, endometriosis and recurrent miscarriage.
Original languageEnglish
Pages (from-to)42-51
Number of pages10
JournalMolecular and Cellular Endocrinology
Volume335
Issue number1
DOIs
Publication statusPublished - 2011

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