Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells

Mohammad M Ahasan; Rowan Hardy; Christopher Jones; Kirren Kaur; Dominika Nanus; Maria Juarez; Stuart A Morgan; Zaki Hassan-Smith; Cécile Bénézech; Jorge H Caamaño; Martin Hewison; Gareth Lavery; Elizabeth H Rabbitt; Andrew R Clark; Andrew Filer; Christopher D Buckley; Karim Raza; Paul M Stewart; Mark S Cooper

doi:10.1002/art.34414

Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells

Mohammad M Ahasan, Rowan Hardy, Christopher Jones, Kirren Kaur, Dominika Nanus, Maria Juarez, Stuart A Morgan, Zaki Hassan-Smith, Cécile Bénézech, Jorge H Caamaño, Martin Hewison, Gareth Lavery, Elizabeth H Rabbitt, Andrew R Clark, Andrew Filer, Christopher D Buckley, Karim Raza, Paul M Stewart, Mark S Cooper

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Tissue glucocorticoid (GC) levels are regulated by the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme is expressed in cells and tissues arising from mesenchymal stromal cells. Proinflammatory cytokines dramatically increase expression of 11β-HSD1 in stromal cells, an effect that has been implicated in inflammatory arthritis, osteoporosis, obesity, and myopathy. Additionally, GCs act synergistically with proinflammatory cytokines to further increase enzyme expression. The present study was undertaken to investigate the mechanisms underlying this regulation.

Original language	English
Pages (from-to)	2404-13
Number of pages	10
Journal	Arthritis and rheumatism
Volume	64
Issue number	7
DOIs	https://doi.org/10.1002/art.34414
Publication status	Published - Jul 2012

Keywords / Materials (for Non-textual outputs)

11-beta-Hydroxysteroid Dehydrogenase Type 1
Animals
Arthritis, Rheumatoid
Cells, Cultured
Cytokines
Fibroblasts
Glucocorticoids
Humans
Inflammation
Interleukin-1beta
Mesenchymal Stromal Cells
Mice
NF-kappa B
Osteoarthritis
Synovial Membrane

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10.1002/art.34414

Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cellsFinal published version, 428 KB

http://onlinelibrary.wiley.com/doi/10.1002/art.34414/abstract

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Ahasan, M. M., Hardy, R., Jones, C., Kaur, K., Nanus, D., Juarez, M., Morgan, S. A., Hassan-Smith, Z., Bénézech, C., Caamaño, J. H., Hewison, M., Lavery, G., Rabbitt, E. H., Clark, A. R., Filer, A., Buckley, C. D., Raza, K., Stewart, P. M., & Cooper, M. S. (2012). Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells. Arthritis and rheumatism, 64(7), 2404-13. https://doi.org/10.1002/art.34414

@article{debcd5a0b3294d3e896fdff93370fa47,

title = "Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells",

abstract = "Tissue glucocorticoid (GC) levels are regulated by the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme is expressed in cells and tissues arising from mesenchymal stromal cells. Proinflammatory cytokines dramatically increase expression of 11β-HSD1 in stromal cells, an effect that has been implicated in inflammatory arthritis, osteoporosis, obesity, and myopathy. Additionally, GCs act synergistically with proinflammatory cytokines to further increase enzyme expression. The present study was undertaken to investigate the mechanisms underlying this regulation.",

keywords = "11-beta-Hydroxysteroid Dehydrogenase Type 1, Animals, Arthritis, Rheumatoid, Cells, Cultured, Cytokines, Fibroblasts, Glucocorticoids, Humans, Inflammation, Interleukin-1beta, Mesenchymal Stromal Cells, Mice, NF-kappa B, Osteoarthritis, Synovial Membrane",

author = "Ahasan, {Mohammad M} and Rowan Hardy and Christopher Jones and Kirren Kaur and Dominika Nanus and Maria Juarez and Morgan, {Stuart A} and Zaki Hassan-Smith and C{\'e}cile B{\'e}n{\'e}zech and Caama{\~n}o, {Jorge H} and Martin Hewison and Gareth Lavery and Rabbitt, {Elizabeth H} and Clark, {Andrew R} and Andrew Filer and Buckley, {Christopher D} and Karim Raza and Stewart, {Paul M} and Cooper, {Mark S}",

note = "Copyright {\textcopyright} 2012 by the American College of Rheumatology.",

year = "2012",

month = jul,

doi = "10.1002/art.34414",

language = "English",

volume = "64",

pages = "2404--13",

journal = "Arthritis and rheumatism",

issn = "0004-3591",

publisher = "Wiley",

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Ahasan, MM, Hardy, R, Jones, C, Kaur, K, Nanus, D, Juarez, M, Morgan, SA, Hassan-Smith, Z, Bénézech, C, Caamaño, JH, Hewison, M, Lavery, G, Rabbitt, EH, Clark, AR, Filer, A, Buckley, CD, Raza, K, Stewart, PM & Cooper, MS 2012, 'Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells', Arthritis and rheumatism, vol. 64, no. 7, pp. 2404-13. https://doi.org/10.1002/art.34414

TY - JOUR

T1 - Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells

AU - Ahasan, Mohammad M

AU - Hardy, Rowan

AU - Jones, Christopher

AU - Kaur, Kirren

AU - Nanus, Dominika

AU - Juarez, Maria

AU - Morgan, Stuart A

AU - Hassan-Smith, Zaki

AU - Bénézech, Cécile

AU - Caamaño, Jorge H

AU - Hewison, Martin

AU - Lavery, Gareth

AU - Rabbitt, Elizabeth H

AU - Clark, Andrew R

AU - Filer, Andrew

AU - Buckley, Christopher D

AU - Raza, Karim

AU - Stewart, Paul M

AU - Cooper, Mark S

PY - 2012/7

Y1 - 2012/7

N2 - Tissue glucocorticoid (GC) levels are regulated by the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme is expressed in cells and tissues arising from mesenchymal stromal cells. Proinflammatory cytokines dramatically increase expression of 11β-HSD1 in stromal cells, an effect that has been implicated in inflammatory arthritis, osteoporosis, obesity, and myopathy. Additionally, GCs act synergistically with proinflammatory cytokines to further increase enzyme expression. The present study was undertaken to investigate the mechanisms underlying this regulation.

AB - Tissue glucocorticoid (GC) levels are regulated by the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme is expressed in cells and tissues arising from mesenchymal stromal cells. Proinflammatory cytokines dramatically increase expression of 11β-HSD1 in stromal cells, an effect that has been implicated in inflammatory arthritis, osteoporosis, obesity, and myopathy. Additionally, GCs act synergistically with proinflammatory cytokines to further increase enzyme expression. The present study was undertaken to investigate the mechanisms underlying this regulation.

KW - 11-beta-Hydroxysteroid Dehydrogenase Type 1

KW - Animals

KW - Arthritis, Rheumatoid

KW - Cells, Cultured

KW - Cytokines

KW - Fibroblasts

KW - Glucocorticoids

KW - Humans

KW - Inflammation

KW - Interleukin-1beta

KW - Mesenchymal Stromal Cells

KW - Mice

KW - NF-kappa B

KW - Osteoarthritis

KW - Synovial Membrane

U2 - 10.1002/art.34414

DO - 10.1002/art.34414

M3 - Article

C2 - 22294469

SN - 0004-3591

VL - 64

SP - 2404

EP - 2413

JO - Arthritis and rheumatism

JF - Arthritis and rheumatism

IS - 7

ER -

Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells

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