Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells

Mohammad M Ahasan, Rowan Hardy, Christopher Jones, Kirren Kaur, Dominika Nanus, Maria Juarez, Stuart A Morgan, Zaki Hassan-Smith, Cécile Bénézech, Jorge H Caamaño, Martin Hewison, Gareth Lavery, Elizabeth H Rabbitt, Andrew R Clark, Andrew Filer, Christopher D Buckley, Karim Raza, Paul M Stewart, Mark S Cooper

Research output: Contribution to journalArticlepeer-review


Tissue glucocorticoid (GC) levels are regulated by the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme is expressed in cells and tissues arising from mesenchymal stromal cells. Proinflammatory cytokines dramatically increase expression of 11β-HSD1 in stromal cells, an effect that has been implicated in inflammatory arthritis, osteoporosis, obesity, and myopathy. Additionally, GCs act synergistically with proinflammatory cytokines to further increase enzyme expression. The present study was undertaken to investigate the mechanisms underlying this regulation.
Original languageEnglish
Pages (from-to)2404-13
Number of pages10
JournalArthritis and rheumatism
Issue number7
Publication statusPublished - Jul 2012


  • 11-beta-Hydroxysteroid Dehydrogenase Type 1
  • Animals
  • Arthritis, Rheumatoid
  • Cells, Cultured
  • Cytokines
  • Fibroblasts
  • Glucocorticoids
  • Humans
  • Inflammation
  • Interleukin-1beta
  • Mesenchymal Stromal Cells
  • Mice
  • NF-kappa B
  • Osteoarthritis
  • Synovial Membrane


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