Influence of cholesterol on survival after stroke: Retrospective study

AG Dyker*, CJ Weir, KR Lees

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: To investigate the association between Serum cholesterol concentration and cerebrovascular disease.

Design: Retrospective study.

Setting: Acute stroke unit of inner city general hospital.

Subjects: 977 patients with acute stroke.

Main outcome measures: Serum total cholesterol concentration, type of stroke investigated by computed tomography or magnetic resonance imaging, three month outcome (good (alive at home) or bad (dead ol in care)), long term mortality

Results: After adjustment for known prognostic factors, higher serum cholesterol concentrations were associated with reduced long term mortality after stroke (relative hazard 0.91 (95% confidence interval 0.84 to 0,98) per mmol/l increase in cholesterol) independently of stroke type, vascular territory and extent, age, and hyperglycaemia. Three month outcome was also influenced independently by serum cholesterol (P = 0.024).

Conclusions: Our data suggest an association between poor stroke outcome and lower serum cholesterol concentration. Until a prospective controlled study has confirmed the benefits of lowering cholesterol concentration in elderly subjects, the application of cholesterol lowering guidelines cannot be justified as secondary prevention of acute stroke.

Original languageEnglish
Pages (from-to)1584-1588
Number of pages9
JournalBritish Medical Journal (BMJ)
Issue number7094
Publication statusPublished - 31 May 1997


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