Abstract
Obesity is associated with increased inactivation of cortisol by hepatic A-ring 5alpha- and 5beta-reductases, impaired hepatic regeneration of cortisol from cortisone by 11beta-hydroxysteroid dehydrogenase type 1 (11HSD1), but increased subcutaneous adipose 11HSD1 activity enhancing local cortisol levels in fat. Cause and effect between obesity and abnormal cortisol metabolism is untested.
Original language | English |
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Pages (from-to) | 185-94 |
Number of pages | 10 |
Journal | European Journal of Endocrinology |
Volume | 150 |
Issue number | 2 |
Publication status | Published - 2004 |