Influenza A virus and the cell nucleus

Maria Joao Amorim, Paul Digard

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

It is over 20 years since the publication of experiments that showed that influenza A virus RNA synthesis takes place in the cell nucleus and that here, the virus subverts the cellular transcription machinery to express and replicate its own single-strand RNA genome. In the years since, our understanding of the organisation of the nucleus has increased enormously, particularly with regards to the functional integration of the RNA polymerase II transcriptosome. This review summarises recent progress in defining the intimate association between the viral and cellular transcriptional machinery.
Original languageEnglish
Pages (from-to)6651-5
Number of pages5
JournalVaccine
Volume24
Issue number44-46
DOIs
Publication statusPublished - 10 Nov 2006

Keywords

  • Animals
  • Cell Nucleus/enzymology
  • Cell Nucleus/virology
  • Humans
  • Influenza A virus/genetics
  • Influenza A virus/physiology
  • Orthomyxoviridae Infections/enzymology
  • Orthomyxoviridae Infections/genetics
  • Orthomyxoviridae Infections/pathology
  • Transcription, Genetic
  • Viral Proteins/genetics
  • Viral Proteins/metabolism
  • Virus Replication

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