Informative Subtyping of Patients with Sepsis

John Cafferkey, Manu Shankar-Hari

Research output: Contribution to journalArticlepeer-review

Abstract

Sepsis pathobiology is complex. Heterogeneity refers to the clinical and biological variation within sepsis cohorts. Sepsis subtypes refer to subpopulations within sepsis cohorts derived based on these observable variations and latent features. The overarching goal of such endeavors is to enable precision immunomodulation. However, we are yet to identify immune endotypes of sepsis to achieve this goal. The sepsis subtyping field is just starting to take shape. The current subtypes in the literature do not have a core set of shared features between studies. Thus, in this narrative review, we reason that there is a need to a priori state the purpose of sepsis subtyping and minimum set of features that would be required to achieve the goal of precision immunomodulation for future sepsis.

Original languageEnglish
Pages (from-to)516-522
JournalSeminars in respiratory and critical care medicine
Volume45
Issue number4
Early online date8 Jul 2024
DOIs
Publication statusPublished - Aug 2024

Keywords / Materials (for Non-textual outputs)

  • critical care
  • endotypes
  • infectious disease
  • phenotypes
  • precision medicine
  • sepsis
  • subtypes

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