Infrequent vertical transmission of hepatitis C virus

J P Lam, F McOmish, S M Burns, P L Yap, J Y Mok, P Simmonds

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The rate of vertical transmission of hepatitis C virus (HCV) was determined by a combination of assays for anti-HCV antibody and the polymerase chain reaction (PCR) in 66 children born to infected mothers. Only 4 children showed evidence of infection with HCV, being positive for anti-HCV in all samples collected from 6 months to 5 years of age. All samples from the remaining 62 children were repeatedly anti-HCV-negative on screening by two second-generation antibody assays. Furthermore, samples collected at age 12 months from 30 antibody-negative children born of HCV-infected mothers were uniformly PCR-negative, showing that "seronegative" infection with HCV was rare or absent in this study group. Serologic reactivity to HCV-encoded antigens in samples from infected children was largely confined to the HCV core protein. Infection with human immunodeficiency virus in the mother was not a significant cofactor for mother-to-child transmission of HCV.
Original languageEnglish
Pages (from-to)572-6
Number of pages5
JournalThe Journal of Infectious Diseases
Issue number3
Publication statusPublished - Mar 1993

Keywords / Materials (for Non-textual outputs)

  • Child, Preschool
  • Cohort Studies
  • Female
  • HIV Infections
  • Hepacivirus
  • Hepatitis Antibodies
  • Hepatitis C
  • Humans
  • Immunoblotting
  • Immunoenzyme Techniques
  • Infant
  • Male
  • Mothers
  • Polymerase Chain Reaction
  • Pregnancy
  • Pregnancy Complications, Infectious
  • RNA, Viral
  • Retrospective Studies


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