Abstract
The replication of influenza virus in chick embryo fibroblast cells is inhibited by alpha-amanitin added during the first 2 hr of infection at concentrations similar to those required to inhibit cellular DNA-dependent RNA polymerase form II in vivo. Of two periods of increased RNA synthesis observed in cells infected with influenza virus, only the first, occurring from 0 to 2 hr after infection, is sensitive to alpha-amanitin. During this early period, there is a stimulation of the activity of DNA-dependent RNA polymerase II of nuclei isolated from infected cells. The data suggest that DNA transcription mediated by polymerase II is essential for influenza virus replication.
| Original language | English |
|---|---|
| Pages (from-to) | 1421-4 |
| Number of pages | 4 |
| Journal | Proceedings of the National Academy of Sciences (PNAS) |
| Volume | 69 |
| Issue number | 6 |
| Publication status | Published - Jun 1972 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Antiviral Agents
- Cells, Cultured
- Chick Embryo
- DNA
- Depression, Chemical
- Fibroblasts
- Mycotoxins
- Orthomyxoviridae
- Peptides
- RNA
- RNA Nucleotidyltransferases
- Virus Replication
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