Abstract
The CDKN2/INK4A tumour suppressor gene is deleted or mutated in a large number of human cancers. Overexpression of its product, p16, has been shown to block the transition through the G1/S phase of the cell cycle in a pRb-dependent fashion by inhibiting the cyclin D-dependent kinases cdk4 and cdk6. Reconstitution of p16 function in transformed cells is therefore an attractive target for anti-cancer drug design.
Original language | English |
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Pages (from-to) | 84-91 |
Number of pages | 8 |
Journal | Current biology : CB |
Volume | 6 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 1996 |
Keywords
- Amino Acid Sequence
- Carrier Proteins
- Cell Cycle
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase 6
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- Molecular Sequence Data
- Peptides
- Phosphorylation
- Protein-Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Retinoblastoma Protein
- S Phase