Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies

Hannah J. Otton; Ariane Janssen; David J. A. Wyllie

doi:10.1042/BST0371423

Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies

Hannah J. Otton, Ariane Janssen, David J. A. Wyllie

Deanery of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

NMDARs (N-methyl-D-aspartate receptors) are considered to be a target for the inhibitory actions of ethanol. While profound inhibition of both native and recombinant NMDARs can be observed following the application of high concentrations of ethanol the levels of inhibition seen with lower concentrations of ethanol are more modest. Here, we report the effects of inhibiting NMDAR-mediated responses with ethanol concentrations that are experienced during the social consumption of alcohol comparing levels of inhibition seen with 'pure' ethanol with those produced by ethanol contained in three popular single malt whiskies.

Original language	English
Pages (from-to)	1423-1425
Number of pages	3
Journal	Biochemical Society Transactions
Volume	37
Issue number	6
DOIs	https://doi.org/10.1042/BST0371423
Publication status	Published - Dec 2009

Keywords

ethanol
γ-aminobutyric acid type A receptor (GABAAR)
glutamate
glycine
malt whisky
N-methyl-D-aspartate receptor (NMDAR)

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10.1042/BST0371423

http://www.biochemsoctrans.org/bst/037/bst0371423.htm

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title = "Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies",

abstract = "NMDARs (N-methyl-D-aspartate receptors) are considered to be a target for the inhibitory actions of ethanol. While profound inhibition of both native and recombinant NMDARs can be observed following the application of high concentrations of ethanol the levels of inhibition seen with lower concentrations of ethanol are more modest. Here, we report the effects of inhibiting NMDAR-mediated responses with ethanol concentrations that are experienced during the social consumption of alcohol comparing levels of inhibition seen with 'pure' ethanol with those produced by ethanol contained in three popular single malt whiskies.",

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AU - Janssen, Ariane

AU - Wyllie, David J. A.

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AB - NMDARs (N-methyl-D-aspartate receptors) are considered to be a target for the inhibitory actions of ethanol. While profound inhibition of both native and recombinant NMDARs can be observed following the application of high concentrations of ethanol the levels of inhibition seen with lower concentrations of ethanol are more modest. Here, we report the effects of inhibiting NMDAR-mediated responses with ethanol concentrations that are experienced during the social consumption of alcohol comparing levels of inhibition seen with 'pure' ethanol with those produced by ethanol contained in three popular single malt whiskies.

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KW - γ-aminobutyric acid type A receptor (GABAAR)

KW - glutamate

KW - glycine

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JF - Biochemical Society Transactions

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Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies

Abstract

Keywords

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