Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells

Mark S Duxbury, Hiromichi Ito, Michael J Zinner, Stanley W Ashley, Edward E Whang

Research output: Contribution to journalArticlepeer-review

Abstract

We tested the hypotheses that Src tyrosine kinase overactivity represents a chemoresistance mechanism and that Src inhibition may enhance gemcitabine cytotoxicity in pancreatic adenocarcinoma cells.
Original languageEnglish
Pages (from-to)2307-18
Number of pages12
JournalClinical Cancer Research
Volume10
Issue number7
Publication statusPublished - 2004

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