Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells

Mark S Duxbury; Hiromichi Ito; Michael J Zinner; Stanley W Ashley; Edward E Whang

Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells

Mark S Duxbury, Hiromichi Ito, Michael J Zinner, Stanley W Ashley, Edward E Whang

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We tested the hypotheses that Src tyrosine kinase overactivity represents a chemoresistance mechanism and that Src inhibition may enhance gemcitabine cytotoxicity in pancreatic adenocarcinoma cells.

Original language	English
Pages (from-to)	2307-18
Number of pages	12
Journal	Clinical Cancer Research
Volume	10
Issue number	7
Publication status	Published - 2004

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title = "Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells",

abstract = "We tested the hypotheses that Src tyrosine kinase overactivity represents a chemoresistance mechanism and that Src inhibition may enhance gemcitabine cytotoxicity in pancreatic adenocarcinoma cells.",

author = "Duxbury, {Mark S} and Hiromichi Ito and Zinner, {Michael J} and Ashley, {Stanley W} and Whang, {Edward E}",

year = "2004",

language = "English",

volume = "10",

pages = "2307--18",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

number = "7",

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TY - JOUR

T1 - Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells

AU - Duxbury, Mark S

AU - Ito, Hiromichi

AU - Zinner, Michael J

AU - Ashley, Stanley W

AU - Whang, Edward E

PY - 2004

Y1 - 2004

N2 - We tested the hypotheses that Src tyrosine kinase overactivity represents a chemoresistance mechanism and that Src inhibition may enhance gemcitabine cytotoxicity in pancreatic adenocarcinoma cells.

AB - We tested the hypotheses that Src tyrosine kinase overactivity represents a chemoresistance mechanism and that Src inhibition may enhance gemcitabine cytotoxicity in pancreatic adenocarcinoma cells.

M3 - Article

C2 - 15073106

VL - 10

SP - 2307

EP - 2318

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 7

ER -

Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells

Abstract

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