Inhibition of type III secretion in Salmonella enterica serovar typhimurium by small-molecule inhibitors

Debra L. Hudson; Abigail N. Layton; Terry R. Field; Alison J. Bowen; Hans Wolf-Watz; Mikael Elofsson; Mark P. Stevens; Edouard E. Galyov

doi:10.1128/AAC.01492-06

Inhibition of type III secretion in Salmonella enterica serovar typhimurium by small-molecule inhibitors

Debra L. Hudson, Abigail N. Layton, Terry R. Field, Alison J. Bowen, Hans Wolf-Watz, Mikael Elofsson, Mark P. Stevens, Edouard E. Galyov

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.

Original language	English
Pages (from-to)	2631-2635
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	7
DOIs	https://doi.org/10.1128/AAC.01492-06
Publication status	Published - Jul 2007

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10.1128/AAC.01492-06

Inhibition of type III secretion in Salmonella enterica serovar typhimurium by small-molecule inhibitors
Copyright © 2007, American Society for Microbiology
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http://aac.asm.org/content/51/7/2631

Cite this

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title = "Inhibition of type III secretion in Salmonella enterica serovar typhimurium by small-molecule inhibitors",

abstract = "Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.",

author = "Hudson, \{Debra L.\} and Layton, \{Abigail N.\} and Field, \{Terry R.\} and Bowen, \{Alison J.\} and Hans Wolf-Watz and Mikael Elofsson and Stevens, \{Mark P.\} and Galyov, \{Edouard E.\}",

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AU - Hudson, Debra L.

AU - Layton, Abigail N.

AU - Field, Terry R.

AU - Bowen, Alison J.

AU - Wolf-Watz, Hans

AU - Elofsson, Mikael

AU - Stevens, Mark P.

AU - Galyov, Edouard E.

PY - 2007/7

Y1 - 2007/7

N2 - Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.

AB - Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.

UR - https://www.scopus.com/pages/publications/34447273555

U2 - 10.1128/AAC.01492-06

DO - 10.1128/AAC.01492-06

M3 - Article

SN - 0066-4804

VL - 51

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EP - 2635

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 7

ER -

Inhibition of type III secretion in Salmonella enterica serovar typhimurium by small-molecule inhibitors

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