Inhibitors of the FEZ-1 metallo-beta-lactamase

Benoit M. R. Lienard, Louise E. Horsfall, Moreno Galleni, Jean-Marie Frere, Christopher J. Schofield

Research output: Contribution to journalArticlepeer-review

Abstract

Metallo-beta-lactamases (MBLs) catalyze the hydrolysis of beta-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a K-i of 6.1 +/- 0.71 mu M against the FEZ-1 MBL but does not significantly inhibit the IMP-1, Bell, CphA or L1 MBLs. (c) 2006 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)964-968
Number of pages5
JournalBioorganic & Medicinal Chemistry Letters
Volume17
Issue number4
DOIs
Publication statusPublished - 15 Feb 2007

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