Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, E S Lander, L M Linton, B Birren, C Nusbaum, M C Zody, J Baldwin, K Devon, K Dewar, M Doyle, W FitzHugh, R Funke, D Gage, K Harris, A Heaford, J Howland, L Kann, J Lehoczky, R LeVine, P McEwanK McKernan, J Meldrim, J P Mesirov, C Miranda, W Morris, J Naylor, C Raymond, M Rosetti, R Santos, A Sheridan, C Sougnez, Y Stange-Thomann, N Stojanovic, A Subramanian, D Wyman, J Rogers, J Sulston, R Ainscough, S Beck, D Bentley, J Burton, C Clee, N Carter, A Coulson, R Deadman, P Deloukas, A Dunham, I Dunham, R Durbin, L French, C P Ponting

Research output: Contribution to journalArticlepeer-review

Abstract

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.

Original languageEnglish
Pages (from-to)860-921
Number of pages62
JournalNature
Volume409
Issue number6822
DOIs
Publication statusPublished - 15 Feb 2001

Keywords

  • Animals
  • Chromosome Mapping
  • Conserved Sequence
  • CpG Islands
  • DNA Transposable Elements
  • Databases, Factual
  • Drug Industry
  • Evolution, Molecular
  • Forecasting
  • GC Rich Sequence
  • Gene Duplication
  • Genes
  • Genetic Diseases, Inborn
  • Genetics, Medical
  • Genome, Human
  • Human Genome Project
  • Humans
  • Mutation
  • Private Sector
  • Proteins
  • Proteome
  • Public Sector
  • RNA
  • Repetitive Sequences, Nucleic Acid
  • Sequence Analysis, DNA
  • Species Specificity

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