Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium; E S Lander; L M Linton; B Birren; C Nusbaum; M C Zody; J Baldwin; K Devon; K Dewar; M Doyle; W FitzHugh; R Funke; D Gage; K Harris; A Heaford; J Howland; L Kann; J Lehoczky; R LeVine; P McEwan; K McKernan; J Meldrim; J P Mesirov; C Miranda; W Morris; J Naylor; C Raymond; M Rosetti; R Santos; A Sheridan; C Sougnez; Y Stange-Thomann; N Stojanovic; A Subramanian; D Wyman; J Rogers; J Sulston; R Ainscough; S Beck; D Bentley; J Burton; C Clee; N Carter; A Coulson; R Deadman; P Deloukas; A Dunham; I Dunham; R Durbin; L French; C P Ponting

doi:10.1038/35057062

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, E S Lander, L M Linton, B Birren, C Nusbaum, M C Zody, J Baldwin, K Devon, K Dewar, M Doyle, W FitzHugh, R Funke, D Gage, K Harris, A Heaford, J Howland, L Kann, J Lehoczky, R LeVine, P McEwanK McKernan, J Meldrim, J P Mesirov, C Miranda, W Morris, J Naylor, C Raymond, M Rosetti, R Santos, A Sheridan, C Sougnez, Y Stange-Thomann, N Stojanovic, A Subramanian, D Wyman, J Rogers, J Sulston, R Ainscough, S Beck, D Bentley, J Burton, C Clee, N Carter, A Coulson, R Deadman, P Deloukas, A Dunham, I Dunham, R Durbin, L French, C P Ponting

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.

Original language	English
Pages (from-to)	860-921
Number of pages	62
Journal	Nature
Volume	409
Issue number	6822
DOIs	https://doi.org/10.1038/35057062
Publication status	Published - 15 Feb 2001

Keywords

Animals
Chromosome Mapping
Conserved Sequence
CpG Islands
DNA Transposable Elements
Databases, Factual
Drug Industry
Evolution, Molecular
Forecasting
GC Rich Sequence
Gene Duplication
Genes
Genetic Diseases, Inborn
Genetics, Medical
Genome, Human
Human Genome Project
Humans
Mutation
Private Sector
Proteins
Proteome
Public Sector
RNA
Repetitive Sequences, Nucleic Acid
Sequence Analysis, DNA
Species Specificity

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International Human Genome Sequencing Consortium, Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., Doyle, M., FitzHugh, W., Funke, R., Gage, D., Harris, K., Heaford, A., Howland, J., Kann, L., Lehoczky, J., LeVine, R., ... Ponting, C. P. (2001). Initial sequencing and analysis of the human genome. Nature, 409(6822), 860-921. https://doi.org/10.1038/35057062

International Human Genome Sequencing Consortium ; Lander, E S ; Linton, L M ; Birren, B ; Nusbaum, C ; Zody, M C ; Baldwin, J ; Devon, K ; Dewar, K ; Doyle, M ; FitzHugh, W ; Funke, R ; Gage, D ; Harris, K ; Heaford, A ; Howland, J ; Kann, L ; Lehoczky, J ; LeVine, R ; McEwan, P ; McKernan, K ; Meldrim, J ; Mesirov, J P ; Miranda, C ; Morris, W ; Naylor, J ; Raymond, C ; Rosetti, M ; Santos, R ; Sheridan, A ; Sougnez, C ; Stange-Thomann, Y ; Stojanovic, N ; Subramanian, A ; Wyman, D ; Rogers, J ; Sulston, J ; Ainscough, R ; Beck, S ; Bentley, D ; Burton, J ; Clee, C ; Carter, N ; Coulson, A ; Deadman, R ; Deloukas, P ; Dunham, A ; Dunham, I ; Durbin, R ; French, L ; Ponting, C P. / Initial sequencing and analysis of the human genome. In: Nature. 2001 ; Vol. 409, No. 6822. pp. 860-921.

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abstract = "The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.",

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International Human Genome Sequencing Consortium, Lander, ES, Linton, LM, Birren, B, Nusbaum, C, Zody, MC, Baldwin, J, Devon, K, Dewar, K, Doyle, M, FitzHugh, W, Funke, R, Gage, D, Harris, K, Heaford, A, Howland, J, Kann, L, Lehoczky, J, LeVine, R, McEwan, P, McKernan, K, Meldrim, J, Mesirov, JP, Miranda, C, Morris, W, Naylor, J, Raymond, C, Rosetti, M, Santos, R, Sheridan, A, Sougnez, C, Stange-Thomann, Y, Stojanovic, N, Subramanian, A, Wyman, D, Rogers, J, Sulston, J, Ainscough, R, Beck, S, Bentley, D, Burton, J, Clee, C, Carter, N, Coulson, A, Deadman, R, Deloukas, P, Dunham, A, Dunham, I, Durbin, R, French, L & Ponting, CP 2001, 'Initial sequencing and analysis of the human genome', Nature, vol. 409, no. 6822, pp. 860-921. https://doi.org/10.1038/35057062

Initial sequencing and analysis of the human genome. / International Human Genome Sequencing Consortium; Lander, E S; Linton, L M; Birren, B; Nusbaum, C; Zody, M C; Baldwin, J; Devon, K; Dewar, K; Doyle, M; FitzHugh, W; Funke, R; Gage, D; Harris, K; Heaford, A; Howland, J; Kann, L; Lehoczky, J; LeVine, R; McEwan, P; McKernan, K; Meldrim, J; Mesirov, J P; Miranda, C; Morris, W; Naylor, J; Raymond, C; Rosetti, M; Santos, R; Sheridan, A; Sougnez, C; Stange-Thomann, Y; Stojanovic, N; Subramanian, A; Wyman, D; Rogers, J; Sulston, J; Ainscough, R; Beck, S; Bentley, D; Burton, J; Clee, C; Carter, N; Coulson, A; Deadman, R; Deloukas, P; Dunham, A; Dunham, I; Durbin, R; French, L; Ponting, C P.

In: Nature, Vol. 409, No. 6822, 15.02.2001, p. 860-921.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Initial sequencing and analysis of the human genome

AU - International Human Genome Sequencing Consortium

AU - Lander, E S

AU - Linton, L M

AU - Birren, B

AU - Nusbaum, C

AU - Zody, M C

AU - Baldwin, J

AU - Devon, K

AU - Dewar, K

AU - Doyle, M

AU - FitzHugh, W

AU - Funke, R

AU - Gage, D

AU - Harris, K

AU - Heaford, A

AU - Howland, J

AU - Kann, L

AU - Lehoczky, J

AU - LeVine, R

AU - McEwan, P

AU - McKernan, K

AU - Meldrim, J

AU - Mesirov, J P

AU - Miranda, C

AU - Morris, W

AU - Naylor, J

AU - Raymond, C

AU - Rosetti, M

AU - Santos, R

AU - Sheridan, A

AU - Sougnez, C

AU - Stange-Thomann, Y

AU - Stojanovic, N

AU - Subramanian, A

AU - Wyman, D

AU - Rogers, J

AU - Sulston, J

AU - Ainscough, R

AU - Beck, S

AU - Bentley, D

AU - Burton, J

AU - Clee, C

AU - Carter, N

AU - Coulson, A

AU - Deadman, R

AU - Deloukas, P

AU - Dunham, A

AU - Dunham, I

AU - Durbin, R

AU - French, L

AU - Ponting, C P

PY - 2001/2/15

Y1 - 2001/2/15

N2 - The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.

AB - The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.

KW - Animals

KW - Chromosome Mapping

KW - Conserved Sequence

KW - CpG Islands

KW - DNA Transposable Elements

KW - Databases, Factual

KW - Drug Industry

KW - Evolution, Molecular

KW - Forecasting

KW - GC Rich Sequence

KW - Gene Duplication

KW - Genes

KW - Genetic Diseases, Inborn

KW - Genetics, Medical

KW - Genome, Human

KW - Human Genome Project

KW - Humans

KW - Mutation

KW - Private Sector

KW - Proteins

KW - Proteome

KW - Public Sector

KW - RNA

KW - Repetitive Sequences, Nucleic Acid

KW - Sequence Analysis, DNA

KW - Species Specificity

U2 - 10.1038/35057062

DO - 10.1038/35057062

M3 - Article

C2 - 11237011

VL - 409

SP - 860

EP - 921

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6822

ER -