Initial sequencing and comparative analysis of the mouse genome

Robert H Waterston; Kerstin Lindblad-Toh; Ewan Birney; Jane Rogers; Josep F Abril; Pankaj Agarwal; Richa Agarwala; Rachel Ainscough; Marina Alexandersson; Peter An; Stylianos E Antonarakis; John Attwood; Robert Baertsch; Jonathon Bailey; Karen Barlow; Stephan Beck; Eric Berry; Bruce Birren; Toby Bloom; Peer Bork; Marc Botcherby; Nicolas Bray; Michael R Brent; Daniel G Brown; Stephen D Brown; Carol Bult; John Burton; Jonathan Butler; Robert D Campbell; Piero Carninci; Simon Cawley; Francesca Chiaromonte; Asif T Chinwalla; Deanna M Church; Michele Clamp; Christopher Clee; Francis S Collins; Lisa L Cook; Richard R Copley; Alan Coulson; Olivier Couronne; James Cuff; Val Curwen; Tim Cutts; Mark Daly; Robert David; Joy Davies; Kimberly D Delehaunty; Ian Jackson; Chris P Ponting; Mouse Genome Sequencing Consortium

doi:10.1038/nature01262

Initial sequencing and comparative analysis of the mouse genome

Robert H Waterston, Kerstin Lindblad-Toh, Ewan Birney, Jane Rogers, Josep F Abril, Pankaj Agarwal, Richa Agarwala, Rachel Ainscough, Marina Alexandersson, Peter An, Stylianos E Antonarakis, John Attwood, Robert Baertsch, Jonathon Bailey, Karen Barlow, Stephan Beck, Eric Berry, Bruce Birren, Toby Bloom, Peer BorkMarc Botcherby, Nicolas Bray, Michael R Brent, Daniel G Brown, Stephen D Brown, Carol Bult, John Burton, Jonathan Butler, Robert D Campbell, Piero Carninci, Simon Cawley, Francesca Chiaromonte, Asif T Chinwalla, Deanna M Church, Michele Clamp, Christopher Clee, Francis S Collins, Lisa L Cook, Richard R Copley, Alan Coulson, Olivier Couronne, James Cuff, Val Curwen, Tim Cutts, Mark Daly, Robert David, Joy Davies, Kimberly D Delehaunty, Ian Jackson, Chris P Ponting, Mouse Genome Sequencing Consortium

Research output: Contribution to journal › Article › peer-review

Abstract

The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.

Original language	English
Pages (from-to)	520-62
Number of pages	43
Journal	Nature
Volume	420
Issue number	6915
DOIs	https://doi.org/10.1038/nature01262
Publication status	Published - 5 Dec 2002

Keywords

Animals
Base Composition
Chromosomes, Mammalian
Conserved Sequence
CpG Islands
Evolution, Molecular
Gene Expression Regulation
Genes
Genetic Variation
Genome
Genome, Human
Genomics
Humans
Mice
Mice, Knockout
Mice, Transgenic
Models, Animal
Multigene Family
Mutagenesis
Neoplasms
Physical Chromosome Mapping
Proteome
Pseudogenes
Quantitative Trait Loci
RNA, Untranslated
Repetitive Sequences, Nucleic Acid
Selection, Genetic
Sequence Analysis, DNA
Sex Chromosomes
Species Specificity
Synteny

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Waterston, R. H., Lindblad-Toh, K., Birney, E., Rogers, J., Abril, J. F., Agarwal, P., Agarwala, R., Ainscough, R., Alexandersson, M., An, P., Antonarakis, S. E., Attwood, J., Baertsch, R., Bailey, J., Barlow, K., Beck, S., Berry, E., Birren, B., Bloom, T., ... Mouse Genome Sequencing Consortium (2002). Initial sequencing and comparative analysis of the mouse genome. Nature, 420(6915), 520-62. https://doi.org/10.1038/nature01262

Waterston, Robert H ; Lindblad-Toh, Kerstin ; Birney, Ewan ; Rogers, Jane ; Abril, Josep F ; Agarwal, Pankaj ; Agarwala, Richa ; Ainscough, Rachel ; Alexandersson, Marina ; An, Peter ; Antonarakis, Stylianos E ; Attwood, John ; Baertsch, Robert ; Bailey, Jonathon ; Barlow, Karen ; Beck, Stephan ; Berry, Eric ; Birren, Bruce ; Bloom, Toby ; Bork, Peer ; Botcherby, Marc ; Bray, Nicolas ; Brent, Michael R ; Brown, Daniel G ; Brown, Stephen D ; Bult, Carol ; Burton, John ; Butler, Jonathan ; Campbell, Robert D ; Carninci, Piero ; Cawley, Simon ; Chiaromonte, Francesca ; Chinwalla, Asif T ; Church, Deanna M ; Clamp, Michele ; Clee, Christopher ; Collins, Francis S ; Cook, Lisa L ; Copley, Richard R ; Coulson, Alan ; Couronne, Olivier ; Cuff, James ; Curwen, Val ; Cutts, Tim ; Daly, Mark ; David, Robert ; Davies, Joy ; Delehaunty, Kimberly D ; Jackson, Ian ; Ponting, Chris P ; Mouse Genome Sequencing Consortium. / Initial sequencing and comparative analysis of the mouse genome. In: Nature. 2002 ; Vol. 420, No. 6915. pp. 520-62.

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title = "Initial sequencing and comparative analysis of the mouse genome",

abstract = "The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.",

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author = "Waterston, {Robert H} and Kerstin Lindblad-Toh and Ewan Birney and Jane Rogers and Abril, {Josep F} and Pankaj Agarwal and Richa Agarwala and Rachel Ainscough and Marina Alexandersson and Peter An and Antonarakis, {Stylianos E} and John Attwood and Robert Baertsch and Jonathon Bailey and Karen Barlow and Stephan Beck and Eric Berry and Bruce Birren and Toby Bloom and Peer Bork and Marc Botcherby and Nicolas Bray and Brent, {Michael R} and Brown, {Daniel G} and Brown, {Stephen D} and Carol Bult and John Burton and Jonathan Butler and Campbell, {Robert D} and Piero Carninci and Simon Cawley and Francesca Chiaromonte and Chinwalla, {Asif T} and Church, {Deanna M} and Michele Clamp and Christopher Clee and Collins, {Francis S} and Cook, {Lisa L} and Copley, {Richard R} and Alan Coulson and Olivier Couronne and James Cuff and Val Curwen and Tim Cutts and Mark Daly and Robert David and Joy Davies and Delehaunty, {Kimberly D} and Ian Jackson and Ponting, {Chris P} and {Mouse Genome Sequencing Consortium}",

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language = "English",

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Waterston, RH, Lindblad-Toh, K, Birney, E, Rogers, J, Abril, JF, Agarwal, P, Agarwala, R, Ainscough, R, Alexandersson, M, An, P, Antonarakis, SE, Attwood, J, Baertsch, R, Bailey, J, Barlow, K, Beck, S, Berry, E, Birren, B, Bloom, T, Bork, P, Botcherby, M, Bray, N, Brent, MR, Brown, DG, Brown, SD, Bult, C, Burton, J, Butler, J, Campbell, RD, Carninci, P, Cawley, S, Chiaromonte, F, Chinwalla, AT, Church, DM, Clamp, M, Clee, C, Collins, FS, Cook, LL, Copley, RR, Coulson, A, Couronne, O, Cuff, J, Curwen, V, Cutts, T, Daly, M, David, R, Davies, J, Delehaunty, KD, Jackson, I , Ponting, CP & Mouse Genome Sequencing Consortium 2002, 'Initial sequencing and comparative analysis of the mouse genome', Nature, vol. 420, no. 6915, pp. 520-62. https://doi.org/10.1038/nature01262

Initial sequencing and comparative analysis of the mouse genome. / Waterston, Robert H; Lindblad-Toh, Kerstin; Birney, Ewan; Rogers, Jane; Abril, Josep F; Agarwal, Pankaj; Agarwala, Richa; Ainscough, Rachel; Alexandersson, Marina; An, Peter; Antonarakis, Stylianos E; Attwood, John; Baertsch, Robert; Bailey, Jonathon; Barlow, Karen; Beck, Stephan; Berry, Eric; Birren, Bruce; Bloom, Toby; Bork, Peer; Botcherby, Marc; Bray, Nicolas; Brent, Michael R; Brown, Daniel G; Brown, Stephen D; Bult, Carol; Burton, John; Butler, Jonathan; Campbell, Robert D; Carninci, Piero; Cawley, Simon; Chiaromonte, Francesca; Chinwalla, Asif T; Church, Deanna M; Clamp, Michele; Clee, Christopher; Collins, Francis S; Cook, Lisa L; Copley, Richard R; Coulson, Alan; Couronne, Olivier; Cuff, James; Curwen, Val; Cutts, Tim; Daly, Mark; David, Robert; Davies, Joy; Delehaunty, Kimberly D; Jackson, Ian ; Ponting, Chris P; Mouse Genome Sequencing Consortium.

In: Nature, Vol. 420, No. 6915, 05.12.2002, p. 520-62.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Initial sequencing and comparative analysis of the mouse genome

AU - Waterston, Robert H

AU - Lindblad-Toh, Kerstin

AU - Birney, Ewan

AU - Rogers, Jane

AU - Abril, Josep F

AU - Agarwal, Pankaj

AU - Agarwala, Richa

AU - Ainscough, Rachel

AU - Alexandersson, Marina

AU - An, Peter

AU - Antonarakis, Stylianos E

AU - Attwood, John

AU - Baertsch, Robert

AU - Bailey, Jonathon

AU - Barlow, Karen

AU - Beck, Stephan

AU - Berry, Eric

AU - Birren, Bruce

AU - Bloom, Toby

AU - Bork, Peer

AU - Botcherby, Marc

AU - Bray, Nicolas

AU - Brent, Michael R

AU - Brown, Daniel G

AU - Brown, Stephen D

AU - Bult, Carol

AU - Burton, John

AU - Butler, Jonathan

AU - Campbell, Robert D

AU - Carninci, Piero

AU - Cawley, Simon

AU - Chiaromonte, Francesca

AU - Chinwalla, Asif T

AU - Church, Deanna M

AU - Clamp, Michele

AU - Clee, Christopher

AU - Collins, Francis S

AU - Cook, Lisa L

AU - Copley, Richard R

AU - Coulson, Alan

AU - Couronne, Olivier

AU - Cuff, James

AU - Curwen, Val

AU - Cutts, Tim

AU - Daly, Mark

AU - David, Robert

AU - Davies, Joy

AU - Delehaunty, Kimberly D

AU - Jackson, Ian

AU - Ponting, Chris P

AU - Mouse Genome Sequencing Consortium

PY - 2002/12/5

Y1 - 2002/12/5

N2 - The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.

AB - The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.

KW - Animals

KW - Base Composition

KW - Chromosomes, Mammalian

KW - Conserved Sequence

KW - CpG Islands

KW - Evolution, Molecular

KW - Gene Expression Regulation

KW - Genes

KW - Genetic Variation

KW - Genome

KW - Genome, Human

KW - Genomics

KW - Humans

KW - Mice

KW - Mice, Knockout

KW - Mice, Transgenic

KW - Models, Animal

KW - Multigene Family

KW - Mutagenesis

KW - Neoplasms

KW - Physical Chromosome Mapping

KW - Proteome

KW - Pseudogenes

KW - Quantitative Trait Loci

KW - RNA, Untranslated

KW - Repetitive Sequences, Nucleic Acid

KW - Selection, Genetic

KW - Sequence Analysis, DNA

KW - Sex Chromosomes

KW - Species Specificity

KW - Synteny

U2 - 10.1038/nature01262

DO - 10.1038/nature01262

M3 - Article

C2 - 12466850

VL - 420

SP - 520

EP - 562

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6915

ER -