Initial sequencing and comparative analysis of the mouse genome

Robert H Waterston, Kerstin Lindblad-Toh, Ewan Birney, Jane Rogers, Josep F Abril, Pankaj Agarwal, Richa Agarwala, Rachel Ainscough, Marina Alexandersson, Peter An, Stylianos E Antonarakis, John Attwood, Robert Baertsch, Jonathon Bailey, Karen Barlow, Stephan Beck, Eric Berry, Bruce Birren, Toby Bloom, Peer BorkMarc Botcherby, Nicolas Bray, Michael R Brent, Daniel G Brown, Stephen D Brown, Carol Bult, John Burton, Jonathan Butler, Robert D Campbell, Piero Carninci, Simon Cawley, Francesca Chiaromonte, Asif T Chinwalla, Deanna M Church, Michele Clamp, Christopher Clee, Francis S Collins, Lisa L Cook, Richard R Copley, Alan Coulson, Olivier Couronne, James Cuff, Val Curwen, Tim Cutts, Mark Daly, Robert David, Joy Davies, Kimberly D Delehaunty, Ian Jackson, Chris P Ponting, Mouse Genome Sequencing Consortium

Research output: Contribution to journalArticlepeer-review

Abstract

The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.
Original languageEnglish
Pages (from-to)520-62
Number of pages43
JournalNature
Volume420
Issue number6915
DOIs
Publication statusPublished - 5 Dec 2002

Keywords

  • Animals
  • Base Composition
  • Chromosomes, Mammalian
  • Conserved Sequence
  • CpG Islands
  • Evolution, Molecular
  • Gene Expression Regulation
  • Genes
  • Genetic Variation
  • Genome
  • Genome, Human
  • Genomics
  • Humans
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Animal
  • Multigene Family
  • Mutagenesis
  • Neoplasms
  • Physical Chromosome Mapping
  • Proteome
  • Pseudogenes
  • Quantitative Trait Loci
  • RNA, Untranslated
  • Repetitive Sequences, Nucleic Acid
  • Selection, Genetic
  • Sequence Analysis, DNA
  • Sex Chromosomes
  • Species Specificity
  • Synteny

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