Innate immune genes of the chicken MHC and related regions

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Compared to the major histocompatibility complex (MHC) of typical mammals, the chicken BF/BL region is small and simple, with most of the genes playing central roles in the adaptive immune response. However, some genes of the chicken MHC are almost certainly involved in innate immunity, such as the complement component C4 and the lectin-like receptor/ligand gene pair BNK and Blec. The poorly-expressed classical class I molecule BF1 is known to be recognised by natural killer (NK) cells and, analogous to mammalian immune responses, the classical class I molecules BF1 and BF2, the CD1 homologs and the butyrophilin homologs called BG may be recognised by adaptive immune lymphocytes with semi-invariant receptors in a so-called adaptate manner. Moreover, the TRIM and BG regions next to the chicken MHC, along with the genetically-unlinked Y and olfactory/scavenger receptor regions on the same chromosome, have multigene families almost certainly involved in innate and adaptate responses. On this chicken microchromosome, the simplicity of the adaptive immune gene systems contrasts with the complexity of the gene systems potentially involved in innate immunity.
Original languageEnglish
Number of pages11
JournalImmunogenetics
Early online date26 Oct 2021
DOIs
Publication statusE-pub ahead of print - 26 Oct 2021

Keywords / Materials (for Non-textual outputs)

  • avian
  • B locus
  • Y locus
  • PRY-SPRY
  • B30.2

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