Innervation of the developing kidney in vivo and in vitro

Julia Tarnick, Mona Elhendawi, Ian Holland, Ziyuan Chang, Jamie A Davies

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Within the adult kidney, renal neurites can be observed alongside the arteries where they play a role in regulating blood flow. However, their role and localization during development has so far not been described in detail. In other tissues, such as the skin of developing limb buds, neurons play an important role during arterial differentiation. Here, we aim to investigate whether renal nerves could potentially carry out a similar role during arterial development in the mouse kidney. In order to do so, we used whole-mount immunofluorescence staining to identify whether the timing of neuronal innervation correlates with the recruitment of arterial smooth muscle cells. Our results show that neurites innervate the kidney between day 13.5 and 14.5 of development, arriving after the recruitment of smooth muscle actin-positive cells to the renal arteries.
Original languageEnglish
Pages (from-to)1-8
JournalBiology Open
Volume12
DOIs
Publication statusPublished - 31 Jul 2023

Keywords / Materials (for Non-textual outputs)

  • Kidney
  • Development
  • Innervation
  • Neurons

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