Innovative solutions to novel drug development in mental health

T R Insel, V Voon, J S Nye, V J Brown, B M Altevogt, E T Bullmore, G M Goodwin, R J Howard, D J Kupfer, G Malloch, H M Marston, D J Nutt, T W Robbins, S M Stahl, M D Tricklebank, J H Williams, B J Sahakian

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

There are many new advances in neuroscience and mental health which should lead to a greater understanding of the neurobiological dysfunction in neuropsychiatric disorders and new developments for early, effective treatments. To do this, a biomarker approach combining genetic, neuroimaging, cognitive and other biological measures is needed. The aim of this article is to highlight novel approaches for pharmacological and non-pharmacological treatment development. This article suggests approaches that can be taken in the future including novel mechanisms with preliminary clinical validation to provide a toolbox for mechanistic studies and also examples of translation and back-translation. The review also emphasizes the need for clinician-scientists to be trained in a novel way in order to equip them with the conceptual and experimental techniques required, and emphasizes the need for private-public partnership and pre-competitive knowledge exchange. This should lead the way for important new holistic treatment developments to improve cognition, functional outcome and well-being of people with neuropsychiatric disorders.
Original languageEnglish
JournalNeuroscience & Biobehavioral Reviews
Early online date3 Apr 2013
Publication statusPublished - 2013


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