Insights into the immunopathogenesis of malaria using mouse models: Expert Reviews in Molecular Medicine

T.J. Lamb, D.E. Brown, A.J. Potocnik, J. Langhorne

Research output: Contribution to journalArticlepeer-review

Abstract

Malaria kills approximately 1-2 million people every year, mostly in sub-Saharan Africa and in Asia. These deaths are at the most severe end of a scale of pathologies affecting approximately 500 million people per year. Much of the pathogenesis of malaria is caused by inappropriate or excessive immune responses mounted by the body to eliminate malaria parasites. In this review, we examine the evidence that immunopathology is responsible for malaria disease in the context of what we have learnt from animal models of malaria. In particular, we look in detail at the processes involved in endothelial cell damage leading to syndromes such as cerebral malaria, as well as generalised systemic manifestations such as anaemia, cachexia and problems with thermoregulation of the body. We also consider malaria in light of the variation of the severity of disease observed among people, and discuss the contribution from animal models to our understanding of this variation. Finally, we discuss some of the implications of immunopathology, and of host and parasite genetic variation, for the design and implementation of anti-malarial vaccines. © 2006 Cambridge University Press.
Original languageEnglish
Pages (from-to)1-22
Number of pages22
JournalExpert Reviews in Molecular Medicine
Volume8
Issue number6
DOIs
Publication statusPublished - 2006

Keywords

  • immunoglobulin E
  • inducible nitric oxide synthase
  • interleukin 12
  • interleukin 12p40
  • interleukin 13
  • interleukin 1beta
  • interleukin 23
  • interleukin 4
  • leukocyte antigen
  • malaria vaccine
  • tumor necrosis factor alpha
  • anemia
  • brain malaria
  • cachexia
  • cell activation
  • cell damage
  • cell specificity
  • correlation analysis
  • cytokine production
  • disease severity
  • endothelium cell
  • erythrocyte deformability
  • genetic polymorphism
  • genetic variability
  • hemolysis
  • host parasite interaction
  • host resistance
  • human
  • immune response
  • immunopathogenesis
  • immunopathology
  • inflammation
  • malaria
  • medical research
  • nonhuman
  • parasite virulence
  • Plasmodium falciparum
  • priority journal
  • review
  • risk assessment
  • signal transduction
  • Th2 cell
  • thermoregulation
  • upregulation
  • Anemia
  • Animals
  • Disease Models, Animal
  • Host-Parasite Relations
  • Humans
  • Malaria
  • Mice
  • Plasmodium
  • Animalia

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