Projects per year
Abstract
Using a protein scaffold covalently functionalised with a thiamine-inspired N-heterocyclic carbene (NHC), we created an artificial Stetterase (ArtiSt) which catalyses a stereoselective, intramolecular Stetter reaction. We demonstrate that ArtiSt functions under ambient conditions with low catalyst loading. Furthermore, activity can be increased >20 fold by altering the protein scaffold.
Original language | English |
---|---|
Pages (from-to) | 13746-13749 |
Journal | Chemical Communications |
Volume | 60 |
Issue number | 93 |
Early online date | 25 Oct 2024 |
DOIs | |
Publication status | E-pub ahead of print - 25 Oct 2024 |
Fingerprint
Dive into the research topics of 'Installation of an organocatalyst into a protein scaffold creates an artificial Stetterase'. Together they form a unique fingerprint.-
Artificial metalloenzymes as evolvable catalysts for selective chemical synthesis: part 2
1/09/23 → 31/08/26
Project: Research
-
Artificial metalloenzymes as evolvable catalysts for selective chemical synthesis
1/05/19 → 31/08/23
Project: Research