Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer

Graeme Walker; Kenneth MacLeod; Alistair R W Williams; David A Cameron; John F Smyth; Simon P Langdon

doi:10.1158/1078-0432.CCR-06-2245

Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer

Graeme Walker, Kenneth MacLeod, Alistair R W Williams, David A Cameron, John F Smyth, Simon P Langdon

Research output: Contribution to journal › Article › peer-review

Abstract

This study sought to explore the predictive value of the insulin-like growth factor (IGF) binding proteins (IGFBP) as markers of response in ovarian cancer patients treated with the aromatase inhibitor letrozole.

Original language	English
Pages (from-to)	1438-44
Number of pages	7
Journal	Clinical Cancer Research
Volume	13
Issue number	5
DOIs	https://doi.org/10.1158/1078-0432.CCR-06-2245
Publication status	Published - 1 Mar 2007

Keywords / Materials (for Non-textual outputs)

Antineoplastic Agents
CA-125 Antigen
Cell Line, Tumor
Drug Resistance, Neoplasm
Estradiol
Female
Humans
Immunohistochemistry
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor Binding Protein 4
Insulin-Like Growth Factor Binding Protein 5
Insulin-Like Growth Factor Binding Proteins
Nitriles
Ovarian Neoplasms
RNA, Messenger
Receptors, Estrogen
Reverse Transcriptase Polymerase Chain Reaction
Triazoles

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10.1158/1078-0432.CCR-06-2245

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@article{181980e665994ccda42ca6e58d27108b,

title = "Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer",

abstract = "This study sought to explore the predictive value of the insulin-like growth factor (IGF) binding proteins (IGFBP) as markers of response in ovarian cancer patients treated with the aromatase inhibitor letrozole.",

keywords = "Antineoplastic Agents, CA-125 Antigen, Cell Line, Tumor, Drug Resistance, Neoplasm, Estradiol, Female, Humans, Immunohistochemistry, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor Binding Protein 4, Insulin-Like Growth Factor Binding Protein 5, Insulin-Like Growth Factor Binding Proteins, Nitriles, Ovarian Neoplasms, RNA, Messenger, Receptors, Estrogen, Reverse Transcriptase Polymerase Chain Reaction, Triazoles",

author = "Graeme Walker and Kenneth MacLeod and Williams, {Alistair R W} and Cameron, {David A} and Smyth, {John F} and Langdon, {Simon P}",

year = "2007",

month = mar,

day = "1",

doi = "10.1158/1078-0432.CCR-06-2245",

language = "English",

volume = "13",

pages = "1438--44",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

number = "5",

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TY - JOUR

T1 - Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer

AU - Walker, Graeme

AU - MacLeod, Kenneth

AU - Williams, Alistair R W

AU - Cameron, David A

AU - Smyth, John F

AU - Langdon, Simon P

PY - 2007/3/1

Y1 - 2007/3/1

N2 - This study sought to explore the predictive value of the insulin-like growth factor (IGF) binding proteins (IGFBP) as markers of response in ovarian cancer patients treated with the aromatase inhibitor letrozole.

AB - This study sought to explore the predictive value of the insulin-like growth factor (IGF) binding proteins (IGFBP) as markers of response in ovarian cancer patients treated with the aromatase inhibitor letrozole.

KW - Antineoplastic Agents

KW - CA-125 Antigen

KW - Cell Line, Tumor

KW - Drug Resistance, Neoplasm

KW - Estradiol

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Insulin-Like Growth Factor Binding Protein 3

KW - Insulin-Like Growth Factor Binding Protein 4

KW - Insulin-Like Growth Factor Binding Protein 5

KW - Insulin-Like Growth Factor Binding Proteins

KW - Nitriles

KW - Ovarian Neoplasms

KW - RNA, Messenger

KW - Receptors, Estrogen

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Triazoles

U2 - 10.1158/1078-0432.CCR-06-2245

DO - 10.1158/1078-0432.CCR-06-2245

M3 - Article

C2 - 17332286

SN - 1078-0432

VL - 13

SP - 1438

EP - 1444

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 5

ER -

Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer

Abstract

Keywords / Materials (for Non-textual outputs)

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