Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

Daniel Garcia de la Serrana, Daniel J Macqueen

Research output: Contribution to journalReview articlepeer-review


The insulin-like growth factor (Igf) binding protein (Igfbp) family has a broad range of physiological functions and a fascinating evolutionary history. This review focuses on the Igfbps of teleost fishes, where genome duplication events have diversified gene repertoire, function, and physiological regulation-with six core Igfbps expanded into a family of over twenty genes in some lineages. In addition to briefly summarizing the current state of knowledge on teleost Igfbp evolution, function, and expression-level regulation, we highlight gaps in our understanding and promising areas for future work.

Original languageEnglish
Pages (from-to)80
JournalFrontiers in Endocrinology
Publication statusPublished - 12 Mar 2018


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