TY - JOUR
T1 - Integrated Short-term Palliative Rehabilitation to improve quality of life and equitable care access in incurable cancer (INSPIRE)
T2 - a multinational European research project
AU - INSPIRE consortium
AU - Bayly, Joanne
AU - Ahmedzai, Hilde Hjelmeland
AU - Blandini, Maria Grazia
AU - Bressi, Barbara
AU - Caraceni, Augusto Tommaso
AU - Carvalho Vasconcelos, Joana
AU - Costi, Stefania
AU - Fugazzaro, Stefania
AU - Guberti, Monica
AU - Guldin, Mai-Britt
AU - Hauken, May
AU - Higginson, Irene
AU - Laird, Barry J.A.
AU - Ling, Julie
AU - Normand, Charles
AU - Nottelmann, Lise
AU - Oldervoll, Line
AU - Payne, Cathy
AU - Prevost, A. Toby
AU - Stene, Guro B.
AU - Vanzulli, Elisa
AU - Veber, Eduardo
AU - Economos, Guillaume
AU - Maddocks, Matthew
N1 - Funding Information:
The authors acknowledge the work and support of all stakeholders who provided their valuable insights and assistance to INSPIRE’s research. Azienda USL – IRCCS di Reggio Emilia, Italy: Luca Braglia, Dr Barbara Bressi, Silvio Cavuto, Dr Stefania Costi, Virginia Dolcini, Debora Formisano, Dr Stefania Fugazzaro, Dr Monica Guberti and Dr Elena Turola. European Association for Palliative Care: Dr Julie Ling, Fódhla Ní Chéileachair, Dr Cathy Payne and Patricia White. European Cancer Patient Coalition: Nicola Di Flora, Eduardo Agustín Veber and Dr Juan Jose Ventura. Fonden for Almen Praksis, Denmark: Professor Mai-Britt Guldin, Dorthe Nielsen and Dr Lise Nottelmann. Hospices Civils de Lyon, France: Anne-Sophie Belmont, Laure Christophe, Dr Guillaume Economos, Julie Haesebaert, Sophie Jacquin-Courtois, Elise Perceau-Chambard and Julia Romeyer. Fondazione IRCCS Istituto Nazionale dei Tumori, Italy: Dr Maria Grazia Blandini, Constanza Bono, Simona Braghieri, Professor Augusto Tommaso Caraceni, Giovanni Scoazec and Dr Elisa Vanzulli. King’s College London, UK: Dr Joanne Bayly, Emily Boocock, Megan Bowers, Professor Irene Higginson, Professor Matthew Maddocks, Professor Charles Normand, Carmine Petrasso, Professor Toby Prevost and Joana Carvalho Vasconcelos. Lyon Ingénierie Projets, France: Marta Esteban. University of Edinburgh, UK: Dr Barry Laird, Amy McLuskie. Universitet I Bergen, Norway: Dr Hilde Hjelmeland Ahmedzai, Professor May Aasebø Hauken, Professor Line Oldervoll and Dr Guro Birgitte Stene. This study is supported by the National Institute for Health and Care Research (NIHR) Applied Research Collaboration South London (NIHR ARC South London) at King’s College Hospital NHS Foundation Trust. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.
Funding Information:
The authors acknowledge the work and support of all stakeholders who provided their valuable insights and assistance to INSPIRE’s research. Azienda USL – IRCCS di Reggio Emilia, Italy: Luca Braglia, Dr Barbara Bressi, Silvio Cavuto, Dr Stefania Costi, Virginia Dolcini, Debora Formisano, Dr Stefania Fugazzaro, Dr Monica Guberti and Dr Elena Turola. European Association for Palliative Care: Dr Julie Ling, Fódhla Ní Chéileachair, Dr Cathy Payne and Patricia White. European Cancer Patient Coalition: Nicola Di Flora, Eduardo Agustín Veber and Dr Juan Jose Ventura. Fonden for Almen Praksis, Denmark: Professor Mai-Britt Guldin, Dorthe Nielsen and Dr Lise Nottelmann. Hospices Civils de Lyon, France: Anne-Sophie Belmont, Laure Christophe, Dr Guillaume Economos, Julie Haesebaert, Sophie Jacquin-Courtois, Elise Perceau-Chambard and Julia Romeyer. Fondazione IRCCS Istituto Nazionale dei Tumori, Italy: Dr Maria Grazia Blandini, Constanza Bono, Simona Braghieri, Professor Augusto Tommaso Caraceni, Giovanni Scoazec and Dr Elisa Vanzulli. King’s College London, UK: Dr Joanne Bayly, Emily Boocock, Megan Bowers, Professor Irene Higginson, Professor Matthew Maddocks, Professor Charles Normand, Carmine Petrasso, Professor Toby Prevost and Joana Carvalho Vasconcelos. Lyon Ingénierie Projets, France: Marta Esteban. University of Edinburgh, UK: Dr Barry Laird, Amy McLuskie. Universitet I Bergen, Norway: Dr Hilde Hjelmeland Ahmedzai, Professor May Aasebø Hauken, Professor Line Oldervoll and Dr Guro Birgitte Stene. This study is supported by the National Institute for Health and Care Research (NIHR) Applied Research Collaboration South London (NIHR ARC South London) at King’s College Hospital NHS Foundation Trust. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by Horizon Europe (grant no. 101057043) and Innovate UK (grant no. 10,047,799). Funded by the European Union. Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or European Health and Digital Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.
Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by Horizon Europe (grant no. 101057043) and Innovate UK (grant no. 10,047,799). Funded by the European Union. Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or European Health and Digital Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.
Publisher Copyright:
© The Author(s), 2023.
PY - 2023/6/14
Y1 - 2023/6/14
N2 - Background: Disability related to incurable cancer affects over a million Europeans each year and people with cancer rank loss of function among the most common unmet supportive care needs. Objectives: To test the clinical and cost-effectiveness of an integrated short-term palliative rehabilitation intervention, to optimise function and quality of life in people affected by incurable cancer. Design: This is a multinational, parallel group, randomised, controlled, assessor blind, superiority trial. Methods: The INSPIRE consortium brings together leaders in palliative care, oncology and rehabilitation from partner organisations across Europe, with complementary expertise in health service research, trials of complex interventions, mixed-method evaluations, statistics and economics. Partnership with leading European civil society organisations ensures citizen engagement and dissemination at the highest level. We will conduct a multinational randomised controlled trial across five European countries, recruiting participants to assess the effectiveness of palliative rehabilitation for people with incurable cancer on the primary outcome – quality of life – and secondary outcomes including disability, symptom burden and goal attainment. To support trial conduct and enhance analysis of trial data, we will also conduct: comparative analysis of current integration of rehabilitation across oncology and palliative care services; mixed-method evaluations of equity and inclusivity, processes and implementation for the intervention, at patient, health service and health system levels. Finally, we will conduct an evidence synthesis, incorporating INSPIRE findings, and a Delphi consensus to develop an international framework for palliative rehabilitation practice and policy, incorporating indicators, core interventions, outcomes and integration methods. Scientific contribution: If positive, the trial could produce a scalable and equitable intervention to improve function and quality of life in people with incurable cancer and reduce the burden of care for their families. It could also upskill the practitioners involved and motivate future research questions. The intervention could be adapted and integrated into different health systems using existing staff and services, with little or no additional cost.
AB - Background: Disability related to incurable cancer affects over a million Europeans each year and people with cancer rank loss of function among the most common unmet supportive care needs. Objectives: To test the clinical and cost-effectiveness of an integrated short-term palliative rehabilitation intervention, to optimise function and quality of life in people affected by incurable cancer. Design: This is a multinational, parallel group, randomised, controlled, assessor blind, superiority trial. Methods: The INSPIRE consortium brings together leaders in palliative care, oncology and rehabilitation from partner organisations across Europe, with complementary expertise in health service research, trials of complex interventions, mixed-method evaluations, statistics and economics. Partnership with leading European civil society organisations ensures citizen engagement and dissemination at the highest level. We will conduct a multinational randomised controlled trial across five European countries, recruiting participants to assess the effectiveness of palliative rehabilitation for people with incurable cancer on the primary outcome – quality of life – and secondary outcomes including disability, symptom burden and goal attainment. To support trial conduct and enhance analysis of trial data, we will also conduct: comparative analysis of current integration of rehabilitation across oncology and palliative care services; mixed-method evaluations of equity and inclusivity, processes and implementation for the intervention, at patient, health service and health system levels. Finally, we will conduct an evidence synthesis, incorporating INSPIRE findings, and a Delphi consensus to develop an international framework for palliative rehabilitation practice and policy, incorporating indicators, core interventions, outcomes and integration methods. Scientific contribution: If positive, the trial could produce a scalable and equitable intervention to improve function and quality of life in people with incurable cancer and reduce the burden of care for their families. It could also upskill the practitioners involved and motivate future research questions. The intervention could be adapted and integrated into different health systems using existing staff and services, with little or no additional cost.
KW - incurable cancer
KW - palliative care
KW - palliative rehabilitation
KW - quality of life
KW - rehabilitation
UR - http://www.scopus.com/inward/record.url?scp=85162944189&partnerID=8YFLogxK
U2 - 10.1177/26323524231179979
DO - 10.1177/26323524231179979
M3 - Article
AN - SCOPUS:85162944189
SN - 2632-3524
VL - 17
JO - Palliative Care and Social Practice
JF - Palliative Care and Social Practice
ER -