Projects per year
Abstract
Influenza viruses undergo continual antigenic evolution allowing mutant viruses to evade host immunity acquired to previous virus strains. Antigenic phenotype is often assessed through pairwise measurement of cross-reactivity between influenza strains using the hemagglutination inhibition (HI) assay. Here, we extend previous approaches to antigenic cartography, and simultaneously characterize antigenic and genetic evolution by modeling the diffusion of antigenic phenotype over a shared virus phylogeny. Using HI data from influenza lineages A/H3N2, A/H1N1, B/Victoria and B/Yamagata, we determine patterns of antigenic drift across viral lineages, showing that A/H3N2 evolves faster and in a more punctuated fashion than other influenza lineages. We also show that year-to-year antigenic drift appears to drive incidence patterns within each influenza lineage. This work makes possible substantial future advances in investigating the dynamics of influenza and other antigenically-variable pathogens by providing a model that intimately combines molecular and antigenic evolution.
Original language | English |
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Article number | 01914 |
Number of pages | 26 |
Journal | eLIFE |
Volume | 3 |
DOIs | |
Publication status | Published - 4 Feb 2014 |
Keywords
- A H1N1 viruses
- B viruses
- epidemic influenza
- amino acid
- hemagglutinin gene
- sequence analysis
- genomic analyses
- United Kingdom
- drift
- variants
Fingerprint
Dive into the research topics of 'Integrating influenza antigenic dynamics with molecular evolution'. Together they form a unique fingerprint.Projects
- 3 Finished
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VIRAL PHYLOGEOGRAPHY: Evolutionary reconstruction of viral spread in time and space
1/10/10 → 30/09/15
Project: Research
Activities
- 1 Membership of external research organisation
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NIH, Div Int Epidemiol & Populat Studies, Fogarty Int Ctr (External organisation)
Andrew Rambaut (Member)
Sep 2009 → Aug 2015Activity: Membership types › Membership of external research organisation
Profiles
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Andrew Rambaut
- School of Biological Sciences - Personal Chair in Molecular Evolution
Person: Academic: Research Active