Inter- and intra-animal variation of integrative properties of stellate cells in the medial entorhinal cortex

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Abstract

Distinctions between cell types underpin organizational principles for nervous system function. Functional variation also exists between neurons of the same type. This is exemplified by correspondence between grid cell spatial scales and the synaptic integrative properties of stellate cells (SCs) in the medial entorhinal cortex. However, we know little about how functional variability is structured either within or between individuals. Using ex-vivo patch-clamp recordings from up to 55 SCs per mouse, we found that integrative properties vary between mice and, in contrast to the modularity of grid cell spatial scales, have a continuous dorsoventral organization. Our results constrain mechanisms for modular grid firing and provide evidence for inter-animal phenotypic variability among neurons of the same type. We suggest that neuron type properties are tuned to circuit-level set points that vary within and between animals.
Original languageEnglish
Article numbere52258
Number of pages25
JournaleLIFE
Volume2020
Issue number9
Early online date10 Feb 2020
DOIs
Publication statusE-pub ahead of print - 10 Feb 2020

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