Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteins

Michael Seeger, Rasmus Hartmann-Petersen, Caroline R M Wilkinson, Mairi Wallace, Itaru Samejima, Martin S Taylor, Colin Gordon

Research output: Contribution to journalArticlepeer-review

Abstract

Fission yeast Rhp23 and Pus1 represent two families of multiubiquitin chain-binding proteins that associate with the proteasome. We show that both proteins bind to different regions of the proteasome subunit Mts4. The binding site for Pus1 was mapped to a cluster of repetitive sequences also found in the proteasome subunit SpRpn2 and the anaphase-promoting complex/cyclosome (APC/C) subunit Cut4. The putative role of Pus1 as a factor involved in allocation of ubiquitinylated substrates for the proteasome is discussed.
Original languageEnglish
Pages (from-to)16791-6
Number of pages6
JournalJournal of Biological Chemistry
Volume278
Issue number19
DOIs
Publication statusPublished - 2003

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