Abstract / Description of output
Supernatants from in vivo asbestos-activated macrophages failed to show any cytostatic activity against a syngeneic fibrosarcoma cell line in vitro. UICC chrysotile-induced peritoneal exudate cells also failed to demonstrate any growth inhibitory effect on the same cells in Winn assays of tumor growth. Mixing UICC crocidolite with inoculated tumor cells resulted in a dose-dependent inhibition of tumor growth; this could, however, be explained by a direct cytostatic effect on the tumor cells of high doses of crocidolite, which was observed in vitro.
| Original language | English |
|---|---|
| Pages (from-to) | 97-101 |
| Number of pages | 5 |
| Journal | Environmental Health Perspectives |
| Volume | 51 |
| Publication status | Published - Sept 1983 |
Keywords / Materials (for Non-textual outputs)
- 5'-Nucleotidase
- Acid Phosphatase
- ANIMALS
- ASBESTOS
- Cell Division
- Cell Membrane
- Fibrosarcoma
- Lysosomes
- MACROPHAGES
- MICE
- nucleotidases
- Time Factors