Interactions of asbestos-activated macrophages with an experimental fibrosarcoma

Ken Donaldson, J. M. Davis, A Ewing, K James

Research output: Contribution to journalArticlepeer-review

Abstract

Supernatants from in vivo asbestos-activated macrophages failed to show any cytostatic activity against a syngeneic fibrosarcoma cell line in vitro. UICC chrysotile-induced peritoneal exudate cells also failed to demonstrate any growth inhibitory effect on the same cells in Winn assays of tumor growth. Mixing UICC crocidolite with inoculated tumor cells resulted in a dose-dependent inhibition of tumor growth; this could, however, be explained by a direct cytostatic effect on the tumor cells of high doses of crocidolite, which was observed in vitro.
Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalEnvironmental Health Perspectives
Volume51
Publication statusPublished - Sep 1983

Keywords

  • 5'-Nucleotidase
  • Acid Phosphatase
  • ANIMALS
  • ASBESTOS
  • Cell Division
  • Cell Membrane
  • Fibrosarcoma
  • Lysosomes
  • MACROPHAGES
  • MICE
  • nucleotidases
  • Time Factors

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