Interactions of HIV-1 with antigen-presenting cells

Tim Hewson*, Nazir Lone, Marilyn Moore, Sarah Howie

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

There is currently much interest in the numerical and functional loss of antigen-presenting cells (APC) in HIV-1 disease and the contribution that this may make to HIV-1 pathology. The HIV-1 virus can interfere with the normal function of APC in a number of ways involving inappropriate signalling. These include changes in cytokine balance, cell-surface molecule expression and intracellular signalling pathways. This review examines how HIV-1 is able to disregulate APC function and discusses possible outcomes for the function of the immune system.

Original languageEnglish
Pages (from-to)289-303
Number of pages15
JournalImmunology & Cell Biology
Volume77
Issue number4
DOIs
Publication statusPublished - 1 Aug 1999

Keywords / Materials (for Non-textual outputs)

  • Acquired immunodeficiency syndrome
  • Antigen-presenting cells
  • Dendritic cells
  • Human immunodeficiency virus
  • Immune system
  • Macrophages

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