Intercalative DNA binding of the marine anticancer drug variolin B

Alberts Canals; Raquel Arribas-Bosacoma; Fernando Albericio; Mercedes Álvarez; Joan Aymamí; Miquel Coll

doi:10.1038/srep39680

Intercalative DNA binding of the marine anticancer drug variolin B

Alberts Canals, Raquel Arribas-Bosacoma, Fernando Albericio, Mercedes Álvarez, Joan Aymamí, Miquel Coll

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.

Original language	English
Article number	39680
Number of pages	5
Journal	Scientific Reports
Volume	7
DOIs	https://doi.org/10.1038/srep39680
Publication status	Published - 4 Jan 2017

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title = "Intercalative DNA binding of the marine anticancer drug variolin B",

abstract = "Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.",

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AU - Canals, Alberts

AU - Arribas-Bosacoma, Raquel

AU - Albericio, Fernando

AU - Álvarez, Mercedes

AU - Aymamí, Joan

AU - Coll, Miquel

PY - 2017/1/4

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N2 - Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.

AB - Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.

U2 - 10.1038/srep39680

DO - 10.1038/srep39680

M3 - Article

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

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Intercalative DNA binding of the marine anticancer drug variolin B

Abstract

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