Intercalative DNA binding of the marine anticancer drug variolin B

Alberts Canals, Raquel Arribas-Bosacoma, Fernando Albericio, Mercedes Álvarez, Joan Aymamí, Miquel Coll

Research output: Contribution to journalArticlepeer-review


Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.
Original languageEnglish
Article number39680
Number of pages5
JournalScientific Reports
Publication statusPublished - 4 Jan 2017


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