Interferon treatment for chronic hepatitis C infection in hemophiliacs--influence of virus load, genotype, and liver pathology on response

J P Hanley, L M Jarvis, J Andrew, R Dennis, P C Hayes, J Piris, R Lee, P Simmonds, C A Ludlam

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, we assessed the effectiveness of interferon treatment in 31 hemophiliacs with chronic hepatitis C virus (HCV) infection. Interferon alfa-2a (3 MU three times weekly) was administered for 6 months. Response was assessed by both serial alanine transaminase (ALT) and HCV RNA levels measured by a sensitive semiquantitative polymerase chain reaction (PCR) method. HCV genotype was determined by restriction fragment length polymorphism (RFLP), and evidence of changing genotypes during interferon therapy was sought. Severity of liver disease was assessed by both noninvasive and invasive methods, including laparoscopic liver inspection and biopsy. Sustained normalization of ALT levels occurred in eight patients (28%), and seven (24%) became nonviremic as assessed by PCR (
Original languageEnglish
Pages (from-to)1704-9
Number of pages6
JournalBlood
Volume87
Issue number5
Publication statusPublished - 1 Mar 1996

Keywords

  • Adolescent
  • Adult
  • Aged
  • Alanine Transaminase
  • Biological Markers
  • Biopsy
  • Female
  • Follow-Up Studies
  • Genotype
  • HIV Infections
  • Hepacivirus
  • Hepatitis C
  • Hepatitis, Chronic
  • Humans
  • Immunologic Factors
  • Interferon-alpha
  • Liver
  • Liver Cirrhosis
  • Male
  • Middle Aged
  • RNA, Viral
  • Recombinant Proteins
  • Recurrence
  • Treatment Failure
  • Viremia

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