Interleukin-1 regulates hematopoietic progenitor and stem cells in the midgestation mouse fetal liver

Claudia Orelio, Marian Peeters, Esther Haak, Karin van der Horn, Elaine Dzierzak

Research output: Contribution to journalArticlepeer-review

Abstract

Hematopoietic progenitors are generated in the yolk sac and aorta-gonad-mesonephros region during early mouse development. At embryonic day 10.5 the first hematopoietic stem cells emerge in the aorta-gonad-mesonephros. Subsequently, hematopoietic stem cells and progenitors are found in the fetal liver. The fetal liver is a potent hematopoietic site, playing an important role in the expansion and differentiation of hematopoietic progenitors and hematopoietic stem cells. However, little is known concerning the regulation of fetal liver hematopoietic stem cells. In particular, the role of cytokines such as interleukin-1 in the regulation of hematopoietic stem cells in the embryo has been largely unexplored. Recently, we observed that the adult pro-inflammatory cytokine interleukin-1 is involved in regulating aorta-gonad-mesonephros hematopoietic progenitor and hematopoietic stem cell activity. Therefore, we set out to investigate whether interleukin-1 also plays a role in regulating fetal liver progenitor cells and hematopoietic stem cells.
Original languageEnglish
Pages (from-to)462-9
Number of pages8
JournalHaematologica
Volume94
Issue number4
DOIs
Publication statusPublished - Apr 2009

Keywords

  • Animals
  • Embryo, Mammalian
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Interleukin-1
  • Liver
  • Mice
  • Receptors, Interleukin-1 Type I

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