Interleukin 18 receptor 1 gene polymorphisms are associated with asthma

Guohua Zhu; Moira K. B. Whyte; Jorgen Vestbo; Karin Carlsen; Kai-Hakon Carlsen; Warren Lenney; Michael Silverman; Peter Helms; Sreekumar G. Pillai

doi:10.1038/ejhg.2008.67

Interleukin 18 receptor 1 gene polymorphisms are associated with asthma

Guohua Zhu, Moira K. B. Whyte, Jorgen Vestbo, Karin Carlsen, Kai-Hakon Carlsen, Warren Lenney, Michael Silverman, Peter Helms, Sreekumar G. Pillai^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The interleukin 18 receptor (IL18R1) gene is a strong candidate gene for sthma. It has been implicated in the pathophysiology of asthma and maps to an asthma susceptibility locus on chromosome 2q12. The possibility of association between polymorphisms in IL18R1 and asthma was examined by genotyping seven SNPs in 294, 342 and 100 families from Denmark, United Kingdom and Norway and conducting family-based association analyses for asthma, atopic asthma and bronchial hyper-reactivity (BHR) phenotypes. Three SNPs in IL18R1 were associated with asthma (0.01131

Original language	English
Pages (from-to)	1083-1090
Number of pages	8
Journal	European Journal of Human Genetics
Volume	16
Issue number	9
DOIs	https://doi.org/10.1038/ejhg.2008.67
Publication status	Published - Sept 2008

Keywords / Materials (for Non-textual outputs)

asthma
IL18R1
genetic association
haplotype analysis
replication
GENOME-WIDE SEARCH
SINGLE-NUCLEOTIDE POLYMORPHISMS
NF-KAPPA-B
FOUNDER POPULATION
LINKAGE ANALYSIS
RECEPTOR-ALPHA
IGE LEVELS
SUSCEPTIBILITY
DISEASE
CELLS

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10.1038/ejhg.2008.67

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title = "Interleukin 18 receptor 1 gene polymorphisms are associated with asthma",

abstract = "The interleukin 18 receptor (IL18R1) gene is a strong candidate gene for sthma. It has been implicated in the pathophysiology of asthma and maps to an asthma susceptibility locus on chromosome 2q12. The possibility of association between polymorphisms in IL18R1 and asthma was examined by genotyping seven SNPs in 294, 342 and 100 families from Denmark, United Kingdom and Norway and conducting family-based association analyses for asthma, atopic asthma and bronchial hyper-reactivity (BHR) phenotypes. Three SNPs in IL18R1 were associated with asthma (0.01131",

keywords = "asthma, IL18R1, genetic association, haplotype analysis, replication, GENOME-WIDE SEARCH, SINGLE-NUCLEOTIDE POLYMORPHISMS, NF-KAPPA-B, FOUNDER POPULATION, LINKAGE ANALYSIS, RECEPTOR-ALPHA, IGE LEVELS, SUSCEPTIBILITY, DISEASE, CELLS",

author = "Guohua Zhu and Whyte, \{Moira K. B.\} and Jorgen Vestbo and Karin Carlsen and Kai-Hakon Carlsen and Warren Lenney and Michael Silverman and Peter Helms and Pillai, \{Sreekumar G.\}",

year = "2008",

month = sep,

doi = "10.1038/ejhg.2008.67",

language = "English",

volume = "16",

pages = "1083--1090",

journal = "European Journal of Human Genetics",

issn = "1018-4813",

publisher = "Springer Nature",

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T1 - Interleukin 18 receptor 1 gene polymorphisms are associated with asthma

AU - Zhu, Guohua

AU - Whyte, Moira K. B.

AU - Vestbo, Jorgen

AU - Carlsen, Karin

AU - Carlsen, Kai-Hakon

AU - Lenney, Warren

AU - Silverman, Michael

AU - Helms, Peter

AU - Pillai, Sreekumar G.

PY - 2008/9

Y1 - 2008/9

N2 - The interleukin 18 receptor (IL18R1) gene is a strong candidate gene for sthma. It has been implicated in the pathophysiology of asthma and maps to an asthma susceptibility locus on chromosome 2q12. The possibility of association between polymorphisms in IL18R1 and asthma was examined by genotyping seven SNPs in 294, 342 and 100 families from Denmark, United Kingdom and Norway and conducting family-based association analyses for asthma, atopic asthma and bronchial hyper-reactivity (BHR) phenotypes. Three SNPs in IL18R1 were associated with asthma (0.01131

AB - The interleukin 18 receptor (IL18R1) gene is a strong candidate gene for sthma. It has been implicated in the pathophysiology of asthma and maps to an asthma susceptibility locus on chromosome 2q12. The possibility of association between polymorphisms in IL18R1 and asthma was examined by genotyping seven SNPs in 294, 342 and 100 families from Denmark, United Kingdom and Norway and conducting family-based association analyses for asthma, atopic asthma and bronchial hyper-reactivity (BHR) phenotypes. Three SNPs in IL18R1 were associated with asthma (0.01131

KW - asthma

KW - IL18R1

KW - genetic association

KW - haplotype analysis

KW - replication

KW - GENOME-WIDE SEARCH

KW - SINGLE-NUCLEOTIDE POLYMORPHISMS

KW - NF-KAPPA-B

KW - FOUNDER POPULATION

KW - LINKAGE ANALYSIS

KW - RECEPTOR-ALPHA

KW - IGE LEVELS

KW - SUSCEPTIBILITY

KW - DISEASE

KW - CELLS

U2 - 10.1038/ejhg.2008.67

DO - 10.1038/ejhg.2008.67

M3 - Article

SN - 1018-4813

VL - 16

SP - 1083

EP - 1090

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

IS - 9

ER -

Interleukin 18 receptor 1 gene polymorphisms are associated with asthma

Abstract

Keywords / Materials (for Non-textual outputs)

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