Interleukin-4 -590 (C>T), toll-like receptor-2 +2258 (G>A) and matrix metalloproteinase-9 -1562 (C>T) polymorphisms in pre-eclampsia

R Fraser, J J Walker, U V Ekbote, K L Martin, P McShane, N M Orsi

Research output: Contribution to journalArticlepeer-review

Abstract

Functional single nucleotide polymorphisms (SNPs) of interleukin (IL)-4 -590 (C>T), toll-like receptor (TLR)-2 +2258 (G>A) and matrix metalloproteinase (MMP)-9 -1562 (C>T) were examined by polymerase chain reaction-restriction fragment length polymorphism to identify their merit as genetic markers for pre-eclampsia. One hundred and seventeen pre-eclamptic women and 146 control subjects with uncomplicated singleton pregnancies participated in this study, conducted at Leeds General Infirmary and St James's University Hospital. While the TLR-2 +2258 (G>A) and MMP-9 -1562 (C>T) SNPs failed to present any significant association with pre-eclampsia, there was a marked trend for an association between the IL-4 -590 (C>T) SNP and pre-eclampsia (chi(2)= 5.87, P = 0.055), with a prevalence of TT homozygous women in this group (OR 4.455, 95% CI 1.286-15.350).

Original languageEnglish
Pages (from-to)1052-6; discussion 1056
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume115
Issue number8
DOIs
Publication statusPublished - Jul 2008

Keywords

  • Adolescent
  • Adult
  • Case-Control Studies
  • Female
  • Genetic Markers
  • Genetic Predisposition to Disease/genetics
  • Humans
  • Interleukin-4/genetics
  • Matrix Metalloproteinase 9/genetics
  • Polymorphism, Genetic/genetics
  • Pre-Eclampsia/genetics
  • Pregnancy
  • Toll-Like Receptor 2/genetics

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