Abstract
Functional single nucleotide polymorphisms (SNPs) of interleukin (IL)-4 -590 (C>T), toll-like receptor (TLR)-2 +2258 (G>A) and matrix metalloproteinase (MMP)-9 -1562 (C>T) were examined by polymerase chain reaction-restriction fragment length polymorphism to identify their merit as genetic markers for pre-eclampsia. One hundred and seventeen pre-eclamptic women and 146 control subjects with uncomplicated singleton pregnancies participated in this study, conducted at Leeds General Infirmary and St James's University Hospital. While the TLR-2 +2258 (G>A) and MMP-9 -1562 (C>T) SNPs failed to present any significant association with pre-eclampsia, there was a marked trend for an association between the IL-4 -590 (C>T) SNP and pre-eclampsia (chi(2)= 5.87, P = 0.055), with a prevalence of TT homozygous women in this group (OR 4.455, 95% CI 1.286-15.350).
Original language | English |
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Pages (from-to) | 1052-6; discussion 1056 |
Journal | BJOG: An International Journal of Obstetrics and Gynaecology |
Volume | 115 |
Issue number | 8 |
Early online date | 28 Jun 2008 |
DOIs | |
Publication status | Published - Jul 2008 |
Keywords / Materials (for Non-textual outputs)
- Adolescent
- Adult
- Case-Control Studies
- Female
- Genetic Markers
- Genetic Predisposition to Disease/genetics
- Humans
- Interleukin-4/genetics
- Matrix Metalloproteinase 9/genetics
- Polymorphism, Genetic/genetics
- Pre-Eclampsia/genetics
- Pregnancy
- Toll-Like Receptor 2/genetics