Interleukin-4 -590 (C>T), toll-like receptor-2 +2258 (G>A) and matrix metalloproteinase-9 -1562 (C>T) polymorphisms in pre-eclampsia

R Fraser; J J Walker; U V Ekbote; K L Martin; P McShane; N M Orsi

doi:10.1111/j.1471-0528.2008.01771.x

Interleukin-4 -590 (C>T), toll-like receptor-2 +2258 (G>A) and matrix metalloproteinase-9 -1562 (C>T) polymorphisms in pre-eclampsia

R Fraser, J J Walker, U V Ekbote, K L Martin, P McShane, N M Orsi

Research output: Contribution to journal › Article › peer-review

Abstract

Functional single nucleotide polymorphisms (SNPs) of interleukin (IL)-4 -590 (C>T), toll-like receptor (TLR)-2 +2258 (G>A) and matrix metalloproteinase (MMP)-9 -1562 (C>T) were examined by polymerase chain reaction-restriction fragment length polymorphism to identify their merit as genetic markers for pre-eclampsia. One hundred and seventeen pre-eclamptic women and 146 control subjects with uncomplicated singleton pregnancies participated in this study, conducted at Leeds General Infirmary and St James's University Hospital. While the TLR-2 +2258 (G>A) and MMP-9 -1562 (C>T) SNPs failed to present any significant association with pre-eclampsia, there was a marked trend for an association between the IL-4 -590 (C>T) SNP and pre-eclampsia (chi(2)= 5.87, P = 0.055), with a prevalence of TT homozygous women in this group (OR 4.455, 95% CI 1.286-15.350).

Original language	English
Pages (from-to)	1052-6; discussion 1056
Journal	BJOG: An International Journal of Obstetrics and Gynaecology
Volume	115
Issue number	8
DOIs	https://doi.org/10.1111/j.1471-0528.2008.01771.x
Publication status	Published - Jul 2008

Keywords

Adolescent
Adult
Case-Control Studies
Female
Genetic Markers
Genetic Predisposition to Disease/genetics
Humans
Interleukin-4/genetics
Matrix Metalloproteinase 9/genetics
Polymorphism, Genetic/genetics
Pre-Eclampsia/genetics
Pregnancy
Toll-Like Receptor 2/genetics

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10.1111/j.1471-0528.2008.01771.x

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title = "Interleukin-4 -590 (C>T), toll-like receptor-2 +2258 (G>A) and matrix metalloproteinase-9 -1562 (C>T) polymorphisms in pre-eclampsia",

abstract = "Functional single nucleotide polymorphisms (SNPs) of interleukin (IL)-4 -590 (C>T), toll-like receptor (TLR)-2 +2258 (G>A) and matrix metalloproteinase (MMP)-9 -1562 (C>T) were examined by polymerase chain reaction-restriction fragment length polymorphism to identify their merit as genetic markers for pre-eclampsia. One hundred and seventeen pre-eclamptic women and 146 control subjects with uncomplicated singleton pregnancies participated in this study, conducted at Leeds General Infirmary and St James's University Hospital. While the TLR-2 +2258 (G>A) and MMP-9 -1562 (C>T) SNPs failed to present any significant association with pre-eclampsia, there was a marked trend for an association between the IL-4 -590 (C>T) SNP and pre-eclampsia (chi(2)= 5.87, P = 0.055), with a prevalence of TT homozygous women in this group (OR 4.455, 95% CI 1.286-15.350).",

keywords = "Adolescent, Adult, Case-Control Studies, Female, Genetic Markers, Genetic Predisposition to Disease/genetics, Humans, Interleukin-4/genetics, Matrix Metalloproteinase 9/genetics, Polymorphism, Genetic/genetics, Pre-Eclampsia/genetics, Pregnancy, Toll-Like Receptor 2/genetics",

author = "R Fraser and Walker, {J J} and Ekbote, {U V} and Martin, {K L} and P McShane and Orsi, {N M}",

year = "2008",

month = jul,

doi = "10.1111/j.1471-0528.2008.01771.x",

language = "English",

volume = "115",

pages = "1052--6; discussion 1056",

journal = "BJOG: An International Journal of Obstetrics and Gynaecology",

issn = "1470-0328",

publisher = "Wiley",

number = "8",

}

Interleukin-4 -590 (C>T), toll-like receptor-2 +2258 (G>A) and matrix metalloproteinase-9 -1562 (C>T) polymorphisms in pre-eclampsia. / Fraser, R; Walker, J J; Ekbote, U V; Martin, K L; McShane, P; Orsi, N M.

In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 115, No. 8, 07.2008, p. 1052-6; discussion 1056.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Interleukin-4 -590 (C>T), toll-like receptor-2 +2258 (G>A) and matrix metalloproteinase-9 -1562 (C>T) polymorphisms in pre-eclampsia

AU - Fraser, R

AU - Walker, J J

AU - Ekbote, U V

AU - Martin, K L

AU - McShane, P

AU - Orsi, N M

PY - 2008/7

Y1 - 2008/7

N2 - Functional single nucleotide polymorphisms (SNPs) of interleukin (IL)-4 -590 (C>T), toll-like receptor (TLR)-2 +2258 (G>A) and matrix metalloproteinase (MMP)-9 -1562 (C>T) were examined by polymerase chain reaction-restriction fragment length polymorphism to identify their merit as genetic markers for pre-eclampsia. One hundred and seventeen pre-eclamptic women and 146 control subjects with uncomplicated singleton pregnancies participated in this study, conducted at Leeds General Infirmary and St James's University Hospital. While the TLR-2 +2258 (G>A) and MMP-9 -1562 (C>T) SNPs failed to present any significant association with pre-eclampsia, there was a marked trend for an association between the IL-4 -590 (C>T) SNP and pre-eclampsia (chi(2)= 5.87, P = 0.055), with a prevalence of TT homozygous women in this group (OR 4.455, 95% CI 1.286-15.350).

AB - Functional single nucleotide polymorphisms (SNPs) of interleukin (IL)-4 -590 (C>T), toll-like receptor (TLR)-2 +2258 (G>A) and matrix metalloproteinase (MMP)-9 -1562 (C>T) were examined by polymerase chain reaction-restriction fragment length polymorphism to identify their merit as genetic markers for pre-eclampsia. One hundred and seventeen pre-eclamptic women and 146 control subjects with uncomplicated singleton pregnancies participated in this study, conducted at Leeds General Infirmary and St James's University Hospital. While the TLR-2 +2258 (G>A) and MMP-9 -1562 (C>T) SNPs failed to present any significant association with pre-eclampsia, there was a marked trend for an association between the IL-4 -590 (C>T) SNP and pre-eclampsia (chi(2)= 5.87, P = 0.055), with a prevalence of TT homozygous women in this group (OR 4.455, 95% CI 1.286-15.350).

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KW - Adult

KW - Case-Control Studies

KW - Female

KW - Genetic Markers

KW - Genetic Predisposition to Disease/genetics

KW - Humans

KW - Interleukin-4/genetics

KW - Matrix Metalloproteinase 9/genetics

KW - Polymorphism, Genetic/genetics

KW - Pre-Eclampsia/genetics

KW - Pregnancy

KW - Toll-Like Receptor 2/genetics

U2 - 10.1111/j.1471-0528.2008.01771.x

DO - 10.1111/j.1471-0528.2008.01771.x

M3 - Article

C2 - 18651887

VL - 115

SP - 1052-6; discussion 1056

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

IS - 8

ER -

Interleukin-4 -590 (C>T), toll-like receptor-2 +2258 (G>A) and matrix metalloproteinase-9 -1562 (C>T) polymorphisms in pre-eclampsia

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Keywords

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