Interleukin-6 receptor pathways in abdominal aortic aneurysm

Aneurysm Consortium, Seamus C Harrison, Andrew J P Smith, Gregory T Jones, Daniel I Swerdlow, Riaz Rampuri, Matthew J Bown, Lasse Folkersen, Annette F Baas, Gert Jan de Borst, Jan D Blankensteijn, Jacqueline F Price, Yolanda van der Graaf, Stela McLachlan, Obi Agu, Albert Hofman, Andre G Uitterlinden, Anders Franco-Cereceda, Ynte M Ruigrok, F N Van't HofJanet T Powell, Andre M van Rij, Juan P Casas, Per Eriksson, Michael V Holmes, Folkert W Asselbergs, Aroon D Hingorani, Steve E Humphries

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common non-synonymous functional variant (Asp358Ala) in the IL-6R gene (IL6R) and AAA, followed the analysis of the variant both in vitro and in vivo. Inflammation may play a role in the development of abdominal aortic aneurysms (AAA). Interleukin-6 (IL-6) signalling through its receptor (IL-6R) is one pathway that could be exploited pharmacologically. We investigated this using a Mendelian randomization approach.
Original languageEnglish
Pages (from-to)3707-16
Number of pages10
JournalEuropean Heart Journal
Volume34
Issue number48
DOIs
Publication statusPublished - Dec 2013

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