Interleukin-6 receptor pathways in abdominal aortic aneurysm

Aneurysm Consortium; Seamus C Harrison; Andrew J P Smith; Gregory T Jones; Daniel I Swerdlow; Riaz Rampuri; Matthew J Bown; Lasse Folkersen; Annette F Baas; Gert Jan de Borst; Jan D Blankensteijn; Jacqueline F Price; Yolanda van der Graaf; Stela McLachlan; Obi Agu; Albert Hofman; Andre G Uitterlinden; Anders Franco-Cereceda; Ynte M Ruigrok; F N Van't Hof; Janet T Powell; Andre M van Rij; Juan P Casas; Per Eriksson; Michael V Holmes; Folkert W Asselbergs; Aroon D Hingorani; Steve E Humphries

doi:10.1093/eurheartj/ehs354

Interleukin-6 receptor pathways in abdominal aortic aneurysm

Aneurysm Consortium
, Seamus C Harrison
, Andrew J P Smith
, Gregory T Jones
, Daniel I Swerdlow
, Riaz Rampuri
, Matthew J Bown
, Lasse Folkersen
, Annette F Baas
, Gert Jan de Borst
, Jan D Blankensteijn
, Jacqueline F Price
, Yolanda van der Graaf
, Stela McLachlan
, Obi Agu
, Albert Hofman
, Andre G Uitterlinden
, Anders Franco-Cereceda
, Ynte M Ruigrok
, F N Van't Hof

Janet T Powell, Andre M van Rij, Juan P Casas, Per Eriksson, Michael V Holmes, Folkert W Asselbergs, Aroon D Hingorani, Steve E Humphries

Research output: Contribution to journal › Article › peer-review

Abstract

We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common non-synonymous functional variant (Asp358Ala) in the IL-6R gene (IL6R) and AAA, followed the analysis of the variant both in vitro and in vivo. Inflammation may play a role in the development of abdominal aortic aneurysms (AAA). Interleukin-6 (IL-6) signalling through its receptor (IL-6R) is one pathway that could be exploited pharmacologically. We investigated this using a Mendelian randomization approach.

Original language	English
Pages (from-to)	3707-16
Number of pages	10
Journal	European Heart Journal
Volume	34
Issue number	48
DOIs	https://doi.org/10.1093/eurheartj/ehs354
Publication status	Published - Dec 2013

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10.1093/eurheartj/ehs354

Interleukin-6 receptor pathways in abdominal aortic aneurysm
© The Author 2012. Published by Oxford University Press on behalf of European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact [email protected].
Final published version, 483 KBLicence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

http://eurheartj.oxfordjournals.org/content/34/48/3707

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Aneurysm Consortium, Harrison, S. C., Smith, A. J. P., Jones, G. T., Swerdlow, D. I., Rampuri, R., Bown, M. J., Folkersen, L., Baas, A. F., de Borst, G. J., Blankensteijn, J. D., Price, J. F., van der Graaf, Y., McLachlan, S., Agu, O., Hofman, A., Uitterlinden, A. G., Franco-Cereceda, A., Ruigrok, Y. M., ... Humphries, S. E. (2013). Interleukin-6 receptor pathways in abdominal aortic aneurysm. European Heart Journal, 34(48), 3707-16. https://doi.org/10.1093/eurheartj/ehs354

@article{82f22564e0d14807bf7ecbb418af682b,

title = "Interleukin-6 receptor pathways in abdominal aortic aneurysm",

abstract = "We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common non-synonymous functional variant (Asp358Ala) in the IL-6R gene (IL6R) and AAA, followed the analysis of the variant both in vitro and in vivo. Inflammation may play a role in the development of abdominal aortic aneurysms (AAA). Interleukin-6 (IL-6) signalling through its receptor (IL-6R) is one pathway that could be exploited pharmacologically. We investigated this using a Mendelian randomization approach.",

author = "\{Aneurysm Consortium\} and Harrison, \{Seamus C\} and Smith, \{Andrew J P\} and Jones, \{Gregory T\} and Swerdlow, \{Daniel I\} and Riaz Rampuri and Bown, \{Matthew J\} and Lasse Folkersen and Baas, \{Annette F\} and \{de Borst\}, \{Gert Jan\} and Blankensteijn, \{Jan D\} and Price, \{Jacqueline F\} and \{van der Graaf\}, Yolanda and Stela McLachlan and Obi Agu and Albert Hofman and Uitterlinden, \{Andre G\} and Anders Franco-Cereceda and Ruigrok, \{Ynte M\} and \{Van't Hof\}, \{F N\} and Powell, \{Janet T\} and \{van Rij\}, \{Andre M\} and Casas, \{Juan P\} and Per Eriksson and Holmes, \{Michael V\} and Asselbergs, \{Folkert W\} and Hingorani, \{Aroon D\} and Humphries, \{Steve E\}",

year = "2013",

month = dec,

doi = "10.1093/eurheartj/ehs354",

language = "English",

volume = "34",

pages = "3707--16",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

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}

Aneurysm Consortium, Harrison, SC, Smith, AJP, Jones, GT, Swerdlow, DI, Rampuri, R, Bown, MJ, Folkersen, L, Baas, AF, de Borst, GJ, Blankensteijn, JD, Price, JF, van der Graaf, Y, McLachlan, S, Agu, O, Hofman, A, Uitterlinden, AG, Franco-Cereceda, A, Ruigrok, YM, Van't Hof, FN, Powell, JT, van Rij, AM, Casas, JP, Eriksson, P, Holmes, MV, Asselbergs, FW, Hingorani, AD & Humphries, SE 2013, 'Interleukin-6 receptor pathways in abdominal aortic aneurysm', European Heart Journal, vol. 34, no. 48, pp. 3707-16. https://doi.org/10.1093/eurheartj/ehs354

TY - JOUR

T1 - Interleukin-6 receptor pathways in abdominal aortic aneurysm

AU - Aneurysm Consortium

AU - Harrison, Seamus C

AU - Smith, Andrew J P

AU - Jones, Gregory T

AU - Swerdlow, Daniel I

AU - Rampuri, Riaz

AU - Bown, Matthew J

AU - Folkersen, Lasse

AU - Baas, Annette F

AU - de Borst, Gert Jan

AU - Blankensteijn, Jan D

AU - Price, Jacqueline F

AU - van der Graaf, Yolanda

AU - McLachlan, Stela

AU - Agu, Obi

AU - Hofman, Albert

AU - Uitterlinden, Andre G

AU - Franco-Cereceda, Anders

AU - Ruigrok, Ynte M

AU - Van't Hof, F N

AU - Powell, Janet T

AU - van Rij, Andre M

AU - Casas, Juan P

AU - Eriksson, Per

AU - Holmes, Michael V

AU - Asselbergs, Folkert W

AU - Hingorani, Aroon D

AU - Humphries, Steve E

PY - 2013/12

Y1 - 2013/12

N2 - We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common non-synonymous functional variant (Asp358Ala) in the IL-6R gene (IL6R) and AAA, followed the analysis of the variant both in vitro and in vivo. Inflammation may play a role in the development of abdominal aortic aneurysms (AAA). Interleukin-6 (IL-6) signalling through its receptor (IL-6R) is one pathway that could be exploited pharmacologically. We investigated this using a Mendelian randomization approach.

AB - We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common non-synonymous functional variant (Asp358Ala) in the IL-6R gene (IL6R) and AAA, followed the analysis of the variant both in vitro and in vivo. Inflammation may play a role in the development of abdominal aortic aneurysms (AAA). Interleukin-6 (IL-6) signalling through its receptor (IL-6R) is one pathway that could be exploited pharmacologically. We investigated this using a Mendelian randomization approach.

U2 - 10.1093/eurheartj/ehs354

DO - 10.1093/eurheartj/ehs354

M3 - Article

C2 - 23111417

SN - 0195-668X

VL - 34

SP - 3707

EP - 3716

JO - European Heart Journal

JF - European Heart Journal

IS - 48

ER -

Interleukin-6 receptor pathways in abdominal aortic aneurysm

Abstract

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