Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

IL6R Genetics Consortium Emerging Risk Factors Collaboration, Nadeem Sarwar, Adam S Butterworth, Daniel F Freitag, John Gregson, Peter Willeit, Donal N Gorman, Pei Gao, Danish Saleheen, Augusto Rendon, Christopher P Nelson, Peter S Braund, Alistair S Hall, Daniel I Chasman, Anne Tybjærg-Hansen, John C Chambers, Emelia J Benjamin, Paul W Franks, Robert Clarke, Arthur A M WildeMieke D Trip, Maristella Steri, Jacqueline C M Witteman, Lu Qi, C Ellen van der Schoot, Ulf de Faire, Jeanette Erdmann, Heather M Stringham, Wolfgang Koenig, Daniel J Rader, David Melzer, David Reich, Bruce M Psaty, Marcus E Kleber, Demosthenes B Panagiotakos, Johann Willeit, Patrik Wennberg, Mark Woodward, Svetlana Adamovic, Eric B Rimm, Tom W Meade, Richard F Gillum, Jonathan A Shaffer, Albert Hofman, Altan Onat, Johan Sundström, Sylvia Wassertheil-Smoller, Dan Mellström, John Gallacher, Mary Cushman, James F Wilson

Research output: Contribution to journalArticlepeer-review

Abstract

Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.
Original languageEnglish
Pages (from-to)1205-13
Number of pages9
JournalThe Lancet
Volume379
Issue number9822
DOIs
Publication statusPublished - 2012

Fingerprint

Dive into the research topics of 'Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies'. Together they form a unique fingerprint.

Cite this