International economic analysis of primary prevention of cardiovascular disease with pravastatin in WOSCOPS

J. Caro*, W. Klittich, A. McGuire, I. Ford, D. Pettitt, J. Norrie, J. Shepherd

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Aims. The results of the West of Scotland Coronary Prevention Study (WOSCOPS) demonstrated the clinical benefit of using pravastatin for the primary prevention of cardiovascular disease in hypercholesterolaemic men. To inform decision makers, who must also consider costs, this study assesses the economic efficiency of such an intervention in a broad range of countries. Methods and Results. A generalized model of cardiovascular disease prevention was used to estimate the cost-effectiveness of primary prevention with pravastatin compared to diet alone. This model follows a cohort of hypercholesterolaemic men over a given period quantifying the effect in terms of the avoidance of cardiovascular disease based on treatment-specific risks derived from WOSCOPS data and extensive record-linkage data on disease-specific survival. Country-specific costs are accounted for by expressing all such parameters in terms of the ratio of monthly treatment to that of managing a myocardial infarction. Over a broad range of inputs the cost-effectiveness ratios remain below $25,000 per life years gained, regardless of country. Subgroups with even better economic efficacy can be defined on the basis of higher baseline risk. Conclusions. In contrast to some previous reports, this analysis based on trial data demonstrates that pravastatin provides not only an effective means of primary cardiovascular disease prevention, but also an efficient one.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalEuropean Heart Journal
Volume20
Issue number4
DOIs
Publication statusPublished - 1 Feb 1999

Keywords

  • Cholesterol-lowering
  • Coronary heart disease
  • Cost-effectiveness
  • General economic model
  • Lipids
  • Prevention

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