Interplay of Autophagy, Receptor Tyrosine Kinase Signalling, and Endocytic Trafficking

Jane Fraser, Ainara Gonzalez Cabodevilla, Joanne Simpson, Noor Gammoh

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Vesicular trafficking events play key roles in the compartmentalisation and proper sorting of cellular components. These events have crucial roles in sensing external signals, regulating protein activities, and stimulating cell growth or death decisions. Although mutations in vesicle trafficking players are not direct drivers of cellular transformation, their activities are important in facilitating oncogenic pathways. One such pathway is the sensing of external stimuli and signalling through receptor tyrosine kinases (RTKs). The regulation of RTK activity by the endocytic pathway has been extensively studied. Compelling recent studies have begun to highlight the association between autophagy and RTK signalling. The influence of this interplay on cellular status and its relevance in disease settings will be discussed here.
Original languageEnglish
JournalEssays in biochemistry
DOIs
Publication statusPublished - 12 Dec 2017

Keywords / Materials (for Non-textual outputs)

  • Receptor tyrosine kinases
  • RTKs
  • autophagy
  • cell signalling
  • endocytosis
  • cancer

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