TY - JOUR
T1 - InterPro
T2 - an integrated documentation resource for protein families, domains and functional sites
AU - InterPro Consortium
AU - Mulder, Nicola J
AU - Apweiler, Rolf
AU - Attwood, Terri K
AU - Bairoch, Amos
AU - Bateman, Alex
AU - Binns, David
AU - Biswas, Margaret
AU - Bradley, Paul
AU - Bork, Peer
AU - Bucher, Phillip
AU - Copley, Richard
AU - Courcelle, Emmanuel
AU - Durbin, Richard
AU - Falquet, Laurent
AU - Fleischmann, Wolfgang
AU - Gouzy, Jerome
AU - Griffith-Jones, Sam
AU - Haft, Daniel
AU - Hermjakob, Henning
AU - Hulo, Nicolas
AU - Kahn, Daniel
AU - Kanapin, Alexander
AU - Krestyaninova, Maria
AU - Lopez, Rodrigo
AU - Letunic, Ivica
AU - Orchard, Sandra
AU - Pagni, Marco
AU - Peyruc, David
AU - Ponting, Chris P
AU - Servant, Florence
AU - Sigrist, Christian J A
PY - 2002/9
Y1 - 2002/9
N2 - The exponential increase in the submission of nucleotide sequences to the nucleotide sequence database by genome sequencing centres has resulted in a need for rapid, automatic methods for classification of the resulting protein sequences. There are several signature and sequence cluster-based methods for protein classification, each resource having distinct areas of optimum application owing to the differences in the underlying analysis methods. In recognition of this, InterPro was developed as an integrated documentation resource for protein families, domains and functional sites, to rationalise the complementary efforts of the individual protein signature database projects. The member databases - PRINTS, PROSITE, Pfam, ProDom, SMART and TIGRFAMs - form the InterPro core. Related signatures from each member database are unified into single InterPro entries. Each InterPro entry includes a unique accession number, functional descriptions and literature references, and links are made back to the relevant member database(s). Release 4.0 of InterPro (November 2001) contains 4,691 entries, representing 3,532 families, 1,068 domains, 74 repeats and 15 sites of post-translational modification (PTMs) encoded by different regular expressions, profiles, fingerprints and hidden Markov models (HMMs). Each InterPro entry lists all the matches against SWISS-PROT and TrEMBL (2,141,621 InterPro hits from 586,124 SWISS-PROT and TrEMBL protein sequences). The database is freely accessible for text- and sequence-based searches.
AB - The exponential increase in the submission of nucleotide sequences to the nucleotide sequence database by genome sequencing centres has resulted in a need for rapid, automatic methods for classification of the resulting protein sequences. There are several signature and sequence cluster-based methods for protein classification, each resource having distinct areas of optimum application owing to the differences in the underlying analysis methods. In recognition of this, InterPro was developed as an integrated documentation resource for protein families, domains and functional sites, to rationalise the complementary efforts of the individual protein signature database projects. The member databases - PRINTS, PROSITE, Pfam, ProDom, SMART and TIGRFAMs - form the InterPro core. Related signatures from each member database are unified into single InterPro entries. Each InterPro entry includes a unique accession number, functional descriptions and literature references, and links are made back to the relevant member database(s). Release 4.0 of InterPro (November 2001) contains 4,691 entries, representing 3,532 families, 1,068 domains, 74 repeats and 15 sites of post-translational modification (PTMs) encoded by different regular expressions, profiles, fingerprints and hidden Markov models (HMMs). Each InterPro entry lists all the matches against SWISS-PROT and TrEMBL (2,141,621 InterPro hits from 586,124 SWISS-PROT and TrEMBL protein sequences). The database is freely accessible for text- and sequence-based searches.
KW - Algorithms
KW - Computational Biology
KW - Databases, Protein
KW - Humans
KW - Information Services
KW - Internet
KW - Proteins
KW - Software
M3 - Article
C2 - 12230031
SN - 1467-5463
VL - 3
SP - 225
EP - 235
JO - Briefings in bioinformatics
JF - Briefings in bioinformatics
IS - 3
ER -