Intra-abdominal spindle cell lesions: a review and practical aids to diagnosis

A Al-Nafussi, N A Wong

Research output: Contribution to journalArticlepeer-review


Intra-abdominal spindle cell lesions are uncommon and often present a diagnostic challenge. An important group of such lesions are the gastrointestinal stromal tumours. Other intra-abdominal spindle cell lesions include fibromatosis, various sarcomas-in particular, leiomyosarcoma, liposarcoma, and malignant peripheral nerve sheath tumour-and, in women, endometrial stromal sarcoma. Less common lesions are inflammatory myofibroblastic tumours, the mesenteric spindle cell reactive lesions, retroperitoneal fibrosis, and solitary fibrous tumour. A variety of intra-abdominal tumours of nonmesenchymal origin may have a spindle cell/sarcomatoid morphology; these include sarcomatoid carcinoma, malignant melanoma and, in women, sarcomatoid granulosa cell tumour. Finally, metastatic sarcomas from pelvic or extra-abdominal organs need also be considered. A set of practical aids to the diagnosis of intra-abdominal spindle cell lesions is presented to assist pathologists dealing with such lesions, particularly with regards to the consideration of differential diagnoses.

Original languageEnglish
Pages (from-to)387-402
Number of pages16
Issue number5
Publication statusPublished - May 2001


  • Abdominal Neoplasms
  • Diagnosis, Differential
  • Fibroma
  • Gastrointestinal Neoplasms
  • Humans
  • Sarcoma


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